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Literature summary for 1.4.3.4 extracted from

  • Tadic, A.; Rujescu, D.; Mueller, M.J.; Kohnen, R.; Stassen, H.H.; Dahmen, N.; Szegedi, A.
    A monoamine oxidase B gene variant and short-term antidepressant treatment response (2007), Prog. Neuropsychopharmacol. Biol. Psychiatry, 31, 1370-1377.
    View publication on PubMed

Application

Application Comment Organism
medicine female patients homozygous for the A-allele of monoamine oxidase B have a significantly faster and more pronounced antidepressant treatment response than AG/GG-carriers. In paroxetine-treated females these differences remain statistically significant. In mirtazapine-treated females homozygous for the A-allele compared to AG/GG-carriers, HAMD-17 scores during the study period are constantly and markedly lower, but not statistically different. In males, no association between the MAOB A644G intron 13 SNP and antidepressant treatment response is detected. The MAOB A644G single nucleotide polymorphism is involved in the outcome of treatment with mirtazapine or paroxetine in females with major depression. If replicated, the MAOB A644G polymorphism could be considered useful for prospective confirmatory pharmacogenetic trials in patients with major depression Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27338
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Synonyms

Synonyms Comment Organism
MAOB
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Homo sapiens
monoamine oxidase B
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Homo sapiens