Inhibitors | Comment | Organism | Structure |
---|---|---|---|
11H-indolo[3,2-c]cinnoline | 29% inhibition at 0.05 mM | Rattus norvegicus | |
2-(3-nitrophenyl)-9H-indeno[2,1-d]pyrimidin-9-one | 12% inhibition at 0.001 mM; 5% inhition at 0.001 mM | Rattus norvegicus | |
2-methyl-9H-indeno[2,1-d]pyrimidin-9-one | - |
Rattus norvegicus | |
2-phenyl-2H-indeno[1,2-c]pyridazine-3,5-dione | 46% inhibition at 0.05 mM | Rattus norvegicus | |
2-phenyl-5H-indeno[1,2-d]pyrimidine | 37% inhibition at 0.02 mM | Rattus norvegicus | |
2-phenyl-9H-indeno[2,1-d]pyrimidine | - |
Rattus norvegicus | |
3-(3-aminophenyl)-9H-indeno[1,2-e][1,2,4]triazin-9-one | 12% inhibition at 0.01 mM; 17% inhibition at 0.01 mM | Rattus norvegicus | |
3-(3-nitrophenyl)-5H-indeno[2,1-e][1,2,4]triazin-5-one | 3% inhibition at 0.01 mM | Rattus norvegicus | |
3-(3-nitrophenyl)-9H-indeno[1,2-e][1,2,4]triazin-9-one | 23% inhibition at 0.01 mM | Rattus norvegicus | |
3-(benzyloxy)-5H-indeno[1,2-c]pyridazin-5-one | - |
Rattus norvegicus | |
3-(phenoxymethyl)-5H-indeno[1,2-c]pyridazin-5-one | - |
Rattus norvegicus | |
3-phenyl-9H-indeno[1,2-e][1,2,4]triazin-9-one | 21% inhibition at 0.01 mM | Rattus norvegicus | |
3-[(4-fluorophenoxy)methyl]-5H-indeno[1,2-c]pyridazin-5-one | 12% inhibition at 0.01 mM | Rattus norvegicus | |
3-[[4-(trifluoromethyl)phenoxy]methyl]-5H-indeno[1,2-c]pyridazin-5-one | 48% inhibition at 0.01 mM | Rattus norvegicus | |
4-(4-chlorophenyl)-5H-indeno[1,2-c]pyridazin-5-one | - |
Rattus norvegicus | |
4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one | - |
Rattus norvegicus | |
6,11-dihydro-5H-benzo[a]carbazole | 38% inhibition at 0.025 mM | Rattus norvegicus | |
Clorgyline | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P19643 | - |
- |
Rattus norvegicus | P21396 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
kynuramine + H2O + O2 | - |
Rattus norvegicus | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? | |
kynuramine + H2O + O2 | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Rattus norvegicus |
MAO-B | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00008 | - |
pH 7.4, 37°C | Rattus norvegicus | 3-(3-nitrophenyl)-9H-indeno[1,2-e][1,2,4]triazin-9-one | |
0.000912 | - |
pH 7.4, 37°C | Rattus norvegicus | 3-(3-nitrophenyl)-5H-indeno[2,1-e][1,2,4]triazin-5-one | |
0.0019 | - |
pH 7.4, 37°C | Rattus norvegicus | 3-[(4-fluorophenoxy)methyl]-5H-indeno[1,2-c]pyridazin-5-one | |
0.00251 | - |
pH 7.4, 37°C | Rattus norvegicus | 3-(phenoxymethyl)-5H-indeno[1,2-c]pyridazin-5-one | |
0.00631 | - |
pH 7.4, 37°C | Rattus norvegicus | 3-phenyl-9H-indeno[1,2-e][1,2,4]triazin-9-one | |
0.0094 | - |
pH 7.4, 37°C | Rattus norvegicus | 2-methyl-9H-indeno[2,1-d]pyrimidin-9-one | |
0.012 | - |
pH 7.4, 37°C | Rattus norvegicus | 6,11-dihydro-5H-benzo[a]carbazole | |
0.013 | - |
pH 7.4, 37°C | Rattus norvegicus | 2-phenyl-9H-indeno[2,1-d]pyrimidine | |
0.0167 | - |
pH 7.4, 37°C | Rattus norvegicus | 2-phenyl-9H-indeno[2,1-d]pyrimidine | |
0.018 | - |
pH 7.4, 37°C | Rattus norvegicus | 2-phenyl-5H-indeno[1,2-d]pyrimidine | |
0.0216 | - |
pH 7.4, 37°C | Rattus norvegicus | 4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one | |
0.0297 | - |
pH 7.4, 37°C | Rattus norvegicus | 11H-indolo[3,2-c]cinnoline | |
0.0308 | - |
pH 7.4, 37°C | Rattus norvegicus | 4-(4-chlorophenyl)-5H-indeno[1,2-c]pyridazin-5-one | |
0.034 | - |
pH 7.4, 37°C | Rattus norvegicus | 4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one | |
0.038 | - |
pH 7.4, 37°C | Rattus norvegicus | 2-phenyl-2H-indeno[1,2-c]pyridazine-3,5-dione | |
0.0471 | - |
pH 7.4, 37°C | Rattus norvegicus | 2-methyl-9H-indeno[2,1-d]pyrimidin-9-one | |
0.055 | - |
pH 7.4, 37°C | Rattus norvegicus | 3-(benzyloxy)-5H-indeno[1,2-c]pyridazin-5-one |