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Literature summary for 1.4.3.4 extracted from

  • Carotti, A.; Catto, M.; Leonetti, F.; Campagna, F.; Soto-Otero, R.; Mendez-Alvarez, E.; Thull, U.; Testa, B.; Altomare, C.
    Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives (2007), J. Med. Chem., 50, 5364-5371.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
11H-indolo[3,2-c]cinnoline 29% inhibition at 0.05 mM Rattus norvegicus
2-(3-nitrophenyl)-9H-indeno[2,1-d]pyrimidin-9-one 12% inhibition at 0.001 mM; 5% inhition at 0.001 mM Rattus norvegicus
2-methyl-9H-indeno[2,1-d]pyrimidin-9-one
-
Rattus norvegicus
2-phenyl-2H-indeno[1,2-c]pyridazine-3,5-dione 46% inhibition at 0.05 mM Rattus norvegicus
2-phenyl-5H-indeno[1,2-d]pyrimidine 37% inhibition at 0.02 mM Rattus norvegicus
2-phenyl-9H-indeno[2,1-d]pyrimidine
-
Rattus norvegicus
3-(3-aminophenyl)-9H-indeno[1,2-e][1,2,4]triazin-9-one 12% inhibition at 0.01 mM; 17% inhibition at 0.01 mM Rattus norvegicus
3-(3-nitrophenyl)-5H-indeno[2,1-e][1,2,4]triazin-5-one 3% inhibition at 0.01 mM Rattus norvegicus
3-(3-nitrophenyl)-9H-indeno[1,2-e][1,2,4]triazin-9-one 23% inhibition at 0.01 mM Rattus norvegicus
3-(benzyloxy)-5H-indeno[1,2-c]pyridazin-5-one
-
Rattus norvegicus
3-(phenoxymethyl)-5H-indeno[1,2-c]pyridazin-5-one
-
Rattus norvegicus
3-phenyl-9H-indeno[1,2-e][1,2,4]triazin-9-one 21% inhibition at 0.01 mM Rattus norvegicus
3-[(4-fluorophenoxy)methyl]-5H-indeno[1,2-c]pyridazin-5-one 12% inhibition at 0.01 mM Rattus norvegicus
3-[[4-(trifluoromethyl)phenoxy]methyl]-5H-indeno[1,2-c]pyridazin-5-one 48% inhibition at 0.01 mM Rattus norvegicus
4-(4-chlorophenyl)-5H-indeno[1,2-c]pyridazin-5-one
-
Rattus norvegicus
4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one
-
Rattus norvegicus
6,11-dihydro-5H-benzo[a]carbazole 38% inhibition at 0.025 mM Rattus norvegicus
Clorgyline
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P19643
-
-
Rattus norvegicus P21396
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kynuramine + H2O + O2
-
Rattus norvegicus 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
?
kynuramine + H2O + O2
-
Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
MAO-A
-
Rattus norvegicus
MAO-B
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00008
-
pH 7.4, 37°C Rattus norvegicus 3-(3-nitrophenyl)-9H-indeno[1,2-e][1,2,4]triazin-9-one
0.000912
-
pH 7.4, 37°C Rattus norvegicus 3-(3-nitrophenyl)-5H-indeno[2,1-e][1,2,4]triazin-5-one
0.0019
-
pH 7.4, 37°C Rattus norvegicus 3-[(4-fluorophenoxy)methyl]-5H-indeno[1,2-c]pyridazin-5-one
0.00251
-
pH 7.4, 37°C Rattus norvegicus 3-(phenoxymethyl)-5H-indeno[1,2-c]pyridazin-5-one
0.00631
-
pH 7.4, 37°C Rattus norvegicus 3-phenyl-9H-indeno[1,2-e][1,2,4]triazin-9-one
0.0094
-
pH 7.4, 37°C Rattus norvegicus 2-methyl-9H-indeno[2,1-d]pyrimidin-9-one
0.012
-
pH 7.4, 37°C Rattus norvegicus 6,11-dihydro-5H-benzo[a]carbazole
0.013
-
pH 7.4, 37°C Rattus norvegicus 2-phenyl-9H-indeno[2,1-d]pyrimidine
0.0167
-
pH 7.4, 37°C Rattus norvegicus 2-phenyl-9H-indeno[2,1-d]pyrimidine
0.018
-
pH 7.4, 37°C Rattus norvegicus 2-phenyl-5H-indeno[1,2-d]pyrimidine
0.0216
-
pH 7.4, 37°C Rattus norvegicus 4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one
0.0297
-
pH 7.4, 37°C Rattus norvegicus 11H-indolo[3,2-c]cinnoline
0.0308
-
pH 7.4, 37°C Rattus norvegicus 4-(4-chlorophenyl)-5H-indeno[1,2-c]pyridazin-5-one
0.034
-
pH 7.4, 37°C Rattus norvegicus 4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one
0.038
-
pH 7.4, 37°C Rattus norvegicus 2-phenyl-2H-indeno[1,2-c]pyridazine-3,5-dione
0.0471
-
pH 7.4, 37°C Rattus norvegicus 2-methyl-9H-indeno[2,1-d]pyrimidin-9-one
0.055
-
pH 7.4, 37°C Rattus norvegicus 3-(benzyloxy)-5H-indeno[1,2-c]pyridazin-5-one