Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-N-allylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | selective for MAO-A | Rattus norvegicus | |
1-N-allylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | selective for MAO-B | Rattus norvegicus | |
1-N-allylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | non-selective inhibitor; non-selective inhibitor | Rattus norvegicus | |
1-N-ethylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | selective for MAO-A | Rattus norvegicus | |
1-N-ethylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | selective for MAO-B | Rattus norvegicus | |
1-N-ethylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | non-selective inhibitor; non-selective inhibitor | Rattus norvegicus | |
1-N-methylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | selective for MAO-A | Rattus norvegicus | |
1-N-methylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | selective for MAO-B | Rattus norvegicus | |
1-N-methylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | non-selective inhibitor; non-selective inhibitor | Rattus norvegicus | |
1-N-phenylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | selective for MAO-A | Rattus norvegicus | |
1-N-phenylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | selective for MAO-B | Rattus norvegicus | |
1-N-phenylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | non-selective inhibitor; non-selective inhibitor | Rattus norvegicus | |
additional information | monoamine oxidase-B inhibitors and antiinflammatory agents might be effective in treating AlzheimerÂ’s disease | Rattus norvegicus | |
Pargyline | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P19643 | - |
- |
Rattus norvegicus | P21396 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
p-tyramine + H2O + O2 | MAO-B | Rattus norvegicus | (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Rattus norvegicus |
MAO-B | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0053 | - |
Pargyline | - |
Rattus norvegicus | |
0.0125 | - |
1-N-methylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | pH 7.6, 37°C, selective for MAO-B | Rattus norvegicus | |
0.013 | - |
1-N-methylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | pH 7.6, 37°C, selective for MAO-A, no preincubation | Rattus norvegicus | |
0.024 | - |
1-N-ethylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | pH 7.6, 37°C, MAO-B, selective for MAO-B | Rattus norvegicus | |
0.0269 | - |
1-N-ethylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | pH 7.6, 37°C, selective for MAO-A, no preincubation | Rattus norvegicus | |
0.0333 | - |
1-N-allylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | pH 7.6, 37°C, selective for MAO-A, no preincubation | Rattus norvegicus | |
0.0337 | - |
1-N-allylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | pH 7.6, 37°C, MAO-B, selective for MAO-B | Rattus norvegicus | |
0.0371 | - |
1-N-phenylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | pH 7.6, 37°C, MAO-B, selective for MAO-B | Rattus norvegicus | |
0.0608 | - |
1-N-phenylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | pH 7.6, 37°C, selective for MAO-A, no preincubation | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.029 | - |
pH 7.6, 37°C, selective for MAO-B, no preincubation | Rattus norvegicus | 1-N-methylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | |
0.03 | - |
pH 7.6, 37°C, selective for MAO-A, no preincubation | Rattus norvegicus | 1-N-methylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | |
0.0445 | - |
pH 7.6, 37°C, selective for MAO-A, no preincubation | Rattus norvegicus | 1-N-ethylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | |
0.051 | - |
pH 7.6, 37°C, selective for MAO-B, no preincubation | Rattus norvegicus | 1-N-ethylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | |
0.059 | - |
pH 7.6, 37°C, selective for MAO-B, no preincubation | Rattus norvegicus | 1-N-allylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | |
0.066 | - |
pH 7.6, 37°C, selective for MAO-B, no preincubation | Rattus norvegicus | 1-N-phenylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | |
0.0679 | - |
pH 7.6, 37°C, selective for MAO-A, no preincubation | Rattus norvegicus | 1-N-allylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | |
0.098 | - |
pH 7.6, 37°C, selective for MAO-A, no preincubation | Rattus norvegicus | 1-N-phenylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | |
0.302 | - |
pH 7.6, 37°C, MAO-A, non-selective inhibitor, no preincubation | Rattus norvegicus | 1-N-methylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | |
0.326 | - |
pH 7.6, 37°C, MAO-A, non-selective inhibitor, no preincubation | Rattus norvegicus | 1-N-phenylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | |
0.33 | - |
pH 7.6, 37°C, MAO-A, non-selective inhibitor, no preincubation | Rattus norvegicus | 1-N-ethylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | |
0.345 | - |
pH 7.6, 37°C, MAO-B, non-selective inhibitor, no preincubation | Rattus norvegicus | 1-N-phenylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | |
0.349 | - |
pH 7.6, 37°C, MAO-B, non-selective inhibitor, no preincubation | Rattus norvegicus | 1-N-methylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | |
0.366 | - |
pH 7.6, 37°C, MAO-A, non-selective inhibitor, no preincubation | Rattus norvegicus | 1-N-allylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | |
0.38 | - |
pH 7.6, 37°C, MAO-B, non-selective inhibitor, no preincubation | Rattus norvegicus | 1-N-ethylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole | |
0.39 | - |
pH 7.6, 37°C, MAO-B, non-selective inhibitor, no preincubation | Rattus norvegicus | 1-N-allylthiocarbamoyl-3-(4-methylphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole |