Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-thiocarbamoyl-3-(4-bromophenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | monoamine oxidase A; monoamine oxidase B | Rattus norvegicus | |
1-thiocarbamoyl-3-(4-bromophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | monoamine oxidase A; monoamine oxidase B | Rattus norvegicus | |
1-thiocarbamoyl-3-(4-chlorophenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | monoamine oxidase A; monoamine oxidase B | Rattus norvegicus | |
1-thiocarbamoyl-3-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | monoamine oxidase A; monoamine oxidase B | Rattus norvegicus | |
1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | monoamine oxidase A; monoamine oxidase B | Rattus norvegicus | |
1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | monoamine oxidase A; monoamine oxidase B | Rattus norvegicus | |
1-thiocarbamoyl-3-(4-methylphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | monoamine oxidase A; monoamine oxidase B | Rattus norvegicus | |
1-thiocarbamoyl-3-(4-methylphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | monoamine oxidase A; monoamine oxidase B | Rattus norvegicus | |
Clorgyline | monoamine oxidase A | Rattus norvegicus | |
additional information | no inhibition: 1-thiocarbamoyl-3-phenyl-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole, thiocarbamoyl-3-phenyl-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | Rattus norvegicus | |
Pargyline | monoamine oxidase B | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0215 | - |
p-tyramine | monoamine oxidase A | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27338 | - |
- |
Rattus norvegicus | P21396 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.043 | - |
substrate p-tyramine, monoamine oxidase A | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzylamine + H2O + O2 | monoamine oxidase B | Homo sapiens | benzaldehyde + NH3 + H2O2 | - |
? | |
p-tyramine + H2O + O2 | monoamine oxidase A | Rattus norvegicus | 4-hydroxyphenylethanal + NH3 + H2O2 | - |
? | |
p-tyramine + H2O + O2 | monoamine oxidase B | Rattus norvegicus | 4-hydroxyphenylethanal + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO | - |
Homo sapiens |
MAO-A | - |
Rattus norvegicus |
MAO-B | - |
Rattus norvegicus |
monoamine oxidase A | - |
Rattus norvegicus |
monoamine oxidase B | - |
Rattus norvegicus |
monoamine oxidase B | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00285 | - |
no preincubation, monoamine oxidase B | Rattus norvegicus | Pargyline | |
0.00405 | - |
no preincubation, monoamine oxidase B | Rattus norvegicus | Pargyline | |
0.00416 | - |
monoamine oxidase A | Rattus norvegicus | Clorgyline | |
0.00496 | - |
no preincubation, monoamine oxidase A | Rattus norvegicus | 1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.0067 | - |
no preincubation, monoamine oxidase A | Rattus norvegicus | 1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.0342 | - |
no preincubation, monoamine oxidase A | Rattus norvegicus | 1-thiocarbamoyl-3-(4-chlorophenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.0382 | - |
no preincubation, monoamine oxidase A | Rattus norvegicus | 1-thiocarbamoyl-3-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.0523 | - |
preincubation 60 min, monoamine oxidase B | Rattus norvegicus | 1-thiocarbamoyl-3-(4-methylphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.0638 | - |
preincubation 60 min, monoamine oxidase B | Rattus norvegicus | 1-thiocarbamoyl-3-(4-methylphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.065 | - |
no preincubation, monoamine oxidase B | Rattus norvegicus | 1-thiocarbamoyl-3-(4-methylphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.069 | - |
no preincubation, monoamine oxidase B | Rattus norvegicus | 1-thiocarbamoyl-3-(4-methylphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.2853 | - |
no preincubation, monoamine oxidase A | Rattus norvegicus | 1-thiocarbamoyl-3-(4-bromophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.402 | - |
preincubation 60 min, monoamine oxidase B | Rattus norvegicus | 1-thiocarbamoyl-3-(4-bromophenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.47 | - |
preincubation 60 min, monoamine oxidase B | Rattus norvegicus | 1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.485 | - |
no preincubation, monoamine oxidase B | Rattus norvegicus | 1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.486 | - |
preincubation 60 min, monoamine oxidase B | Rattus norvegicus | 1-thiocarbamoyl-3-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.49 | - |
no preincubation, monoamine oxidase B | Rattus norvegicus | 1-thiocarbamoyl-3-(4-bromophenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.499 | - |
preincubation 60 min, monoamine oxidase B | Rattus norvegicus | 1-thiocarbamoyl-3-(4-bromophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.5 | - |
no preincubation, monoamine oxidase B | Rattus norvegicus | 1-thiocarbamoyl-3-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.5 | - |
preincubation 60 min, monoamine oxidase B | Rattus norvegicus | 1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.5 | - |
preincubation 60 min, monoamine oxidase B | Rattus norvegicus | 1-thiocarbamoyl-3-(4-chlorophenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.501 | - |
no preincubation, monoamine oxidase A | Rattus norvegicus | 1-thiocarbamoyl-3-(4-methylphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.51 | - |
no preincubation, monoamine oxidase B | Rattus norvegicus | 1-thiocarbamoyl-3-(4-bromophenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.51 | - |
no preincubation, monoamine oxidase B | Rattus norvegicus | 1-thiocarbamoyl-3-(4-chlorophenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.513 | - |
no preincubation, monoamine oxidase A | Rattus norvegicus | 1-thiocarbamoyl-3-(4-methylphenyl)-5-(2-chloro-3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole | |
0.53 | - |
no preincubation, monoamine oxidase B | Rattus norvegicus | 1-thiocarbamoyl-3-(4-methoxyphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole |