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Literature summary for 1.4.3.4 extracted from

  • Bortolato, M.; Chen, K.; Shih, J.C.
    Monoamine oxidase inactivation: From pathophysiology to therapeutics (2008), Adv. Drug Deliv. Rev., 60, 1527-1533.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.3.4

Application

Application Comment Organism
medicine the MAO B inhibitor selegiline is efficacious in the therapeutic management of Parkinson's disease Homo sapiens
medicine the MAO inhibitor moclobemide is promising in the therapeutic management of post-traumatic stress disorder and panic disorder Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
moclobemide the MAO inhibitor is promising in the therapeutic management of post-traumatic stress disorder and panic disorder; the MAO inhibitor is promising in the therapeutic management of post-traumatic stress disorder and panic disorder Homo sapiens
selegiline the MAO B inhibitor is efficacious in the therapeutic management of Parkinson's disease Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus MAO A KO mice display attenuated endocrine responses to major stressors, such as restraint, cold temperature, prolonged water deprivation and chronic variable stress ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P21397
-
-
Homo sapiens P27338
-
-
Mus musculus Q64133
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet MAO B is the only isoform in platelets and lymphocytes Homo sapiens
-
fibroblast MAO A is prevalent in fibroblasts and placental tissue Homo sapiens
-
lymphocyte MAO B is the only isoform in platelets and lymphocytes Homo sapiens
-
placenta MAO A is prevalent in fibroblasts and placental tissue Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MAO A KO mice display attenuated endocrine responses to major stressors, such as restraint, cold temperature, prolonged water deprivation and chronic variable stress Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
MAO A
-
 Homo sapiens
MAO A
-
 Mus musculus
MAO B
-
 Homo sapiens
monoamine oxidase
-
 Homo sapiens
monoamine oxidase
-
 Mus musculus