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Literature summary for 1.4.3.4 extracted from

  • Chimenti, F.; Maccioni, E.; Secci, D.; Bolasco, A.; Chimenti, P.; Granese, A.; Befani, O.; Turini, P.; Alcaro, S.; Ortuso, F.; Cirilli, R.; La Torre, F.; Cardia, M.C.; Distinto, S.
    Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)-pyrazole derivatives (2005), J. Med. Chem., 48, 7113-7122.
    View publication on PubMed
Search for more literature for 1.4.3.4

Inhibitors

Inhibitors Comment Organism Structure
3,5-bis(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
3,5-di-2-thienyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
3-(4-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
5-(2-furyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
5-(2-furyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
5-(4-chlorophenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
5-(4-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
5-(4-chlorophenyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus
5-(4-methylphenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus P21398
-
-
Bos taurus P56560
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kynuramine + H2O + O2
-
 Bos taurus 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
MAO-A
-
 Bos taurus
MAO-B
-
 Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000015
-
 5-(4-chlorophenyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
0.000004
-
 5-(2-furyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
0.000006
-
 3,5-bis(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
0.000006
-
 5-(4-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
0.000006
-
 5-(4-chlorophenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
0.000007
-
 3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
0.000008
-
 3-(4-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
0.00001
-
 3,5-bis(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
0.00001
-
 5-(4-methylphenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
0.00002
-
 5-(2-furyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
0.000027
-
 3,5-di-2-thienyl-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
0.000031
-
 5-(4-chlorophenyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
0.000041
-
 5-(4-chlorophenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
0.00005
-
 5-(4-methylphenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
0.00005
-
 5-(2-furyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-A Bos taurus
0.00005
-
 3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
0.00005
-
 3,5-di-2-thienyl-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
0.00017
-
 5-(2-furyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
0.00037
-
 3-(4-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus
0.001
-
 5-(4-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide pH 7.4, 38°C, MAO-B Bos taurus