Crystallization (Comment) | Organism |
---|---|
sitting-drop vapour diffusion method. Crystal structures of MAO B in complex with four of the N-propargylaminoindane class of MAO B inhibitors, rasagiline, N-propargyl-1(S)-aminoindane, 6-hydroxy-N-propargyl-1(R)-aminoindane, and N-methyl-N-propargyl-1(R)-aminoindane are determined at a resolution of better than 2.1 A. Rasagiline, 6-hydroxy-N-propargyl-1(R)-aminoindane, and N-methyl-N-propargyl-1(R)-aminoindane adopt essentially the same conformation with the extended propargyl chain covalently bound to the flavin and the indane ring located in the rear of the substrate cavity. N-propargyl-1(S)-aminoindane binds with the indane ring in a flipped conformation with respect to the other inhibitors, which causes a slight movement of the Tyr326 side chain | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | outer membrane | Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27338 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
MAO B | - |
Homo sapiens |
monoamine oxidase B | - |
Homo sapiens |