Application | Comment | Organism |
---|---|---|
analysis | on-line immobilized enzyme reactors can be used for the on-line screening of substances for MAO-A and substrate/inhibitor properties | Homo sapiens |
analysis | on-line immobilized enzyme reactors can be used for the on-line screening of substrances for MAO-A and substrate/inhibitor properties | Homo sapiens |
General Stability | Organism |
---|---|
membranes containing human MAO-A can be immobilized in an immobilized artificial stationary phase with retention of enzymatic activity | Homo sapiens |
membranes containing human MAO-B can be immobilized in an immobilized artificial stationary phase with retention of enzymatic activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R,2R)-(-)-psi-ephedrine | IC50 for soluble enzyme: 5.03 mM, IC50 for immobilized enzyme: 88 mM, monoamine oxidase B; IC50 for soluble enzyme: 5.35 mM, IC50 for immobilized enzyme: 14.86 mM, monoamine oxidase A | Homo sapiens | |
(1S,2S)-(+)-psi-ephedrine | IC50 for soluble enzyme: 0.88 mM, IC50 for immobilized enzyme: 1.77 mM, monoamine oxidase A; IC50 for soluble enzyme: 10 mM, IC50 for immobilized enzyme: 234 mM, monoamine oxidase B | Homo sapiens | |
(R)-amphetamine | IC50 for soluble enzyme: 0.0311 mM, IC50 for immobilized enzyme: 0.0991 mM, monoamine oxidase A; IC50 for soluble enzyme: 0.246 mM, IC50 for immobilized enzyme: 4.03 mM, monoamine oxidase B | Homo sapiens | |
(R,S)-amphetamine | IC50 for soluble enzyme: 0.0031 mM, IC50 for immobilized enzyme: 0.0244 mM, monoamine oxidase A; IC50 for soluble enzyme: 0.0625 mM, IC50 for immobilized enzyme: 3 mM, monoamine oxidase B | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.2044 | - |
kynuramine | pH 7.5, 37°C, soluble enzyme, monoamine oxidase A | Homo sapiens | |
0.4065 | - |
kynuramine | pH 7.5, 37°C, immobilized enzyme, monoamine oxidase A | Homo sapiens | |
1.045 | - |
kynuramine | pH 7.5, 37°C, soluble enzyme, monoamine oxidase B | Homo sapiens | |
5.123 | - |
kynuramine | pH 7.5, 37°C, immobilized enzyme, monoamine oxidase B | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
kynuramine + H2O + O2 | - |
Homo sapiens | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Homo sapiens |
MAO-B | - |
Homo sapiens |
monoamine oxidase A | - |
Homo sapiens |
monoamine oxidase B | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0244 | - |
IC50 for soluble enzyme: 0.0031 mM, IC50 for immobilized enzyme: 0.0244 mM, monoamine oxidase A | Homo sapiens | (R,S)-amphetamine | |
0.0991 | - |
IC50 for soluble enzyme: 0.0311 mM, IC50 for immobilized enzyme: 0.0991 mM, monoamine oxidase A | Homo sapiens | (R)-amphetamine | |
1.77 | - |
IC50 for soluble enzyme: 0.88 mM, IC50 for immobilized enzyme: 1.77 mM, monoamine oxidase A | Homo sapiens | (1S,2S)-(+)-psi-ephedrine | |
3 | - |
IC50 for soluble enzyme: 0.0625 mM, IC50 for immobilized enzyme: 3 mM, monoamine oxidase B | Homo sapiens | (R,S)-amphetamine | |
4.03 | - |
IC50 for soluble enzyme: 0.246 mM, IC50 for immobilized enzyme: 4.03 mM, monoamine oxidase B | Homo sapiens | (R)-amphetamine | |
14.86 | - |
IC50 for soluble enzyme: 5.35 mM, IC50 for immobilized enzyme: 14.86 mM, monoamine oxidase A | Homo sapiens | (1R,2R)-(-)-psi-ephedrine | |
88 | - |
IC50 for soluble enzyme: 5.03 mM, IC50 for immobilized enzyme: 88 mM, monoamine oxidase B | Homo sapiens | (1R,2R)-(-)-psi-ephedrine | |
234 | - |
IC50 for soluble enzyme: 10 mM, IC50 for immobilized enzyme: 234 mM, monoamine oxidase B | Homo sapiens | (1S,2S)-(+)-psi-ephedrine |