Cloned (Comment) | Organism |
---|---|
advantage of the expression in Pichia pastoris compared with the expression in Saccharomyces cerevisiae: a higher level of homogeneity of the isolated enzyme | Homo sapiens |
expression in Pichia pastoris | Homo sapiens |
expression in Saccharomyces cerevisiae | Homo sapiens |
high-level expression in Pichia pastoris, higher expression level than in Saccharomyces cerevisiae and higher level of homogeneity of the isolated enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Clorgyline | - |
Homo sapiens | |
N-(2-aminoethyl)-aryl-carboxamide | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | comparison of Km of MAO expressed in Saccharomyces cerevisiae and Pichia pastoris | Homo sapiens | |
0.89 | - |
phenethylamine | 11°C | Homo sapiens | |
1.36 | - |
dopamine | 11°C | Homo sapiens | |
2.92 | - |
serotonin | 11°C | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60512 | - |
x * 60512, electrospray mass spectroscopy, including one covalent FAD, MAO-A | Homo sapiens |
60512 | - |
x * 60512, electrospray mass spectrometry | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P21397 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.76 | - |
- |
Homo sapiens |
Storage Stability | Organism |
---|---|
-20°C, in 50% glycerol v/v for up to 5 months without measurable loss of activity | Homo sapiens |
4°C, enzyme desalted by G-25 gel filtration, stable for 30 days | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-phenylethylamine + H2O + O2 | - |
Homo sapiens | 2-phenylethanal + NH3 + H2O2 | - |
? | |
dopamine + H2O + O2 | - |
Homo sapiens | (3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2 | - |
? | |
kynuramine + H2O + O2 | - |
Homo sapiens | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | - |
Homo sapiens | RCHO + NH3 + H2O2 | - |
? | |
serotonin + H2O + O2 | - |
Homo sapiens | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 60512, electrospray mass spectroscopy, including one covalent FAD, MAO-A | Homo sapiens |
? | x * 60512, electrospray mass spectrometry | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Homo sapiens |
monoamine oxidase A | - |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
15 | - |
below, enzyme expressed in Saccharomyces cerevisiae, 60 min stable | Homo sapiens |
20 | - |
enzyme expressed in Pichia pastoris, 60 min stable | Homo sapiens |
20 | - |
enzyme expressed in Saccharomyces cerevisiae, 60 min 15% loss of activity | Homo sapiens |
25 | - |
enzyme expressed in Pichia pastoris, 60 min, 8% loss of activity | Homo sapiens |
25 | - |
enzyme expressed in Saccharomyces cerevisiae, 60 min 50% loss of activity | Homo sapiens |
30 | - |
enzyme expressed in Pichia pastoris, 60 min, 60% loss of activity | Homo sapiens |
30 | - |
enzyme expressed in Saccharomyces cerevisiae, 60 min 80% loss of activity | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.249 | - |
dopamine | 11°C | Homo sapiens | |
0.426 | - |
serotonin | 11°C | Homo sapiens | |
1.481 | - |
phenethylamine | 11°C | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
8alpha-S-cysteinyl-FAD | 1 mol per mol of enzyme | Homo sapiens | |
flavin | MAO-A contain 1 mol of 8-alpha-S-cysteinyl 406 FAD per mol | Homo sapiens |