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Literature summary for 1.4.3.4 extracted from
- Mitochondrial monoamine oxidase. I. Purification and characterization of the bovine kidney enzyme (1967), J. Biol. Chem., 242, 4230-4238.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10 phenanthroline | weak inhibition | Bos taurus |  |
| 2-hydroxyquinoline | reversible by dialysis | Bos taurus | |
| 4-Cyanophenol | weak inhibition | Bos taurus | |
| 8-hydroxyquinoline | reversible by the addition of Zn2+, Ni2+, Co2+ | Bos taurus | |
| alpha-Naphthol | reversible by dialysis | Bos taurus | |
| beta-naphthol | reversible by dialysis | Bos taurus | |
| Sodium diethyldithiocarbamate | weak inhibition | Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.07 | - |
kynuramine | - |
Bos taurus | |
| 0.12 | - |
benzylamine | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Bos taurus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | 0.00014-0.00015 mg copper per mg of protein, nonessential for activity | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzylamine + H2O + O2 | - |
Bos taurus | benzaldehyde + NH3 + H2O2 | - |
? | |
| kynuramine + H2O + O2 | - |
Bos taurus | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? | |
| RCH2NH2 + H2O + O2 | specificity | Bos taurus | RCHO + NH3 + H2O2 | - |
? | |
| RCH2NH2 + H2O + O2 | no activity with histamine | Bos taurus | RCHO + NH3 + H2O2 | - |
? | |
| RCH2NH2 + H2O + O2 | oxidizes primary, secondary and tertiary amines | Bos taurus | RCHO + NH3 + H2O2 | - |
? | |
| RCH2NH2 + H2O + O2 | 5-hydroxytryptamine, MAO-A selective substrate | Bos taurus | RCHO + NH3 + H2O2 | - |
? | |
| tryptamine + H2O + O2 | - |
Bos taurus | 1H-indol-3-yl-acetaldehyde + NH3 + H2O2 | - |
? | |
| tyramine + H2O + O2 | - |
Bos taurus | (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| flavin | 1 mol of flavin: per 100000 g of protein | Bos taurus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1 | - |
beta-naphthol | - |
Bos taurus | |
| 0.2 | - |
alpha-Naphthol | - |
Bos taurus | |
| 0.25 | - |
2-hydroxyquinoline | - |
Bos taurus | |
| 0.65 | - |
8-hydroxyquinoline | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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