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Literature summary for 1.4.3.4 extracted from

  • Schilling, B.; Lerch, K.
    Amine oxidases from Aspergillus niger: identification of a novel flavin-dependent enzyme (1995), Biochim. Biophys. Acta, 1243, 529-537.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Clorgyline
-
Aspergillus niger
Deprenyl
-
Aspergillus niger
Pargyline
-
Aspergillus niger

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
4 * 55000, SDS-PAGE Aspergillus niger
215000
-
gel filtration Aspergillus niger

Organism

Organism UniProt Comment Textmining
Aspergillus niger
-
two amine oxidases isolated: the first one corresponds to the copper-dependent enzyme, the second one is an evolutionary prototype form of MAO-A and B
-

Purification (Commentary)

Purification (Comment) Organism
-
Aspergillus niger

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
Aspergillus niger
-

Storage Stability

Storage Stability Organism
-20°C, stable for several weeks Aspergillus niger

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-phenylethylamine + H2O + O2
-
Aspergillus niger 2-phenylethanal + NH3 + H2O2
-
?
benzylamine + H2O + O2
-
Aspergillus niger benzaldehyde + NH3 + H2O2
-
?
dopamine + H2O + O2
-
Aspergillus niger (3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
?
RCH2NH2 + H2O + O2 no activity with histamine Aspergillus niger RCHO + NH3 + H2O2
-
?
RCH2NH2 + H2O + O2 norepinephrine Aspergillus niger RCHO + NH3 + H2O2
-
?
RCH2NH2 + H2O + O2 no activity with octopamine Aspergillus niger RCHO + NH3 + H2O2
-
?
serotonin + H2O + O2
-
Aspergillus niger (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 55000, SDS-PAGE Aspergillus niger

Cofactor

Cofactor Comment Organism Structure
flavin noncovalently bound flavin Aspergillus niger