Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | L5/L6 spinal nerve ligation in the lumbar spinal cord increases the enzyme activity with an increase in neuropathic pain, mechanical allodynia | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
real-time quantitative PCR expression analysis | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
chlorpromazine | a non-specific DAO inhibitor | Rattus norvegicus | |
Sodium benzoate | competitive inhibitor, inhibits the development of mechanical allodynia, caused by enhanced enzyme expression, in the spinal cord, overview | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Rattus norvegicus | 5777 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-alanine + H2O + O2 | Rattus norvegicus | - |
pyruvate + NH3 + H2O2 | - |
? | |
additional information | Rattus norvegicus | D-amino acid oxidase is an enzyme catalyzing the strict stereospecificity the oxidative deamination of neutral and polar D-amino acids to alpha-keto acids, NH3 and hydrogen peroxide | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
flavoprotein | - |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
central nervous system | DAO is restricted to the lower brainstem, cerebellum and spinal cord, decreasing levels in the midbrain, the cortex and hippocampus | Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
spinal cord | lumbar spinal cord | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-alanine + H2O + O2 | - |
Rattus norvegicus | pyruvate + NH3 + H2O2 | - |
? | |
additional information | D-amino acid oxidase is an enzyme catalyzing the strict stereospecificity the oxidative deamination of neutral and polar D-amino acids to alpha-keto acids, NH3 and hydrogen peroxide | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DAO | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.2 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
flavin | flavoenzyme | Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | L5/L6 spinal nerve ligation in the lumbar spinal cord increases the enzyme expression correlated with an increase in neuropathic pain, mechanical allodynia | up |
General Information | Comment | Organism |
---|---|---|
physiological function | D-amino acid oxidase is an enzyme catalyzing oxidative deamination of neutral and polar D-amino acids. It plays a role in neuropathic pain, in spinal nerve ligation-induced mechanical allodynia, which is specifically blocked by sodium benzoate | Rattus norvegicus |