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Literature summary for 1.4.3.3 extracted from

  • Zhao, W.J.; Gao, Z.Y.; Wei, H.; Nie, H.Z.; Zhao, Q.; Zhou, X.J.; Wang, Y.X.
    Spinal D-amino acid oxidase contributes to neuropathic pain in rats (2009), J. Pharmacol. Exp. Ther., 332, 248-254.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information L5/L6 spinal nerve ligation in the lumbar spinal cord increases the enzyme activity with an increase in neuropathic pain, mechanical allodynia Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
real-time quantitative PCR expression analysis Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
chlorpromazine a non-specific DAO inhibitor Rattus norvegicus
Sodium benzoate competitive inhibitor, inhibits the development of mechanical allodynia, caused by enhanced enzyme expression, in the spinal cord, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
Rattus norvegicus 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-alanine + H2O + O2 Rattus norvegicus
-
pyruvate + NH3 + H2O2
-
?
additional information Rattus norvegicus D-amino acid oxidase is an enzyme catalyzing the strict stereospecificity the oxidative deamination of neutral and polar D-amino acids to alpha-keto acids, NH3 and hydrogen peroxide ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male Wistar rats
-

Posttranslational Modification

Posttranslational Modification Comment Organism
flavoprotein
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
central nervous system DAO is restricted to the lower brainstem, cerebellum and spinal cord, decreasing levels in the midbrain, the cortex and hippocampus Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
spinal cord lumbar spinal cord Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-alanine + H2O + O2
-
Rattus norvegicus pyruvate + NH3 + H2O2
-
?
additional information D-amino acid oxidase is an enzyme catalyzing the strict stereospecificity the oxidative deamination of neutral and polar D-amino acids to alpha-keto acids, NH3 and hydrogen peroxide Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
DAO
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.2
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
flavin flavoenzyme Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus L5/L6 spinal nerve ligation in the lumbar spinal cord increases the enzyme expression correlated with an increase in neuropathic pain, mechanical allodynia up

General Information

General Information Comment Organism
physiological function D-amino acid oxidase is an enzyme catalyzing oxidative deamination of neutral and polar D-amino acids. It plays a role in neuropathic pain, in spinal nerve ligation-induced mechanical allodynia, which is specifically blocked by sodium benzoate Rattus norvegicus