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Literature summary for 1.4.3.3 extracted from

  • Adage, T.; Trillat, A.C.; Quattropani, A.; Perrin, D.; Cavarec, L.; Shaw, J.; Guerassimenko, O.; Giachetti, C.; Greco, B.; Chumakov, I.; Halazy, S.; Roach, A.; Zaratin, P.
    In vitro and in vivo pharmacological profile of AS057278, a selective D-amino acid oxidase inhibitor with potential anti-psychotic properties (2008), Eur. Neuropsychopharmacol., 18, 200-214.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain BL21(DE3) and HEK293-H cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-methylpyrazole-3-carboxylic acid AS057278, selective D-amino acid oxidase inhibitor Homo sapiens
5-methylpyrazole-3-carboxylic acid AS057278, selective D-amino acid oxidase inhibitor, 10 mg/kg Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens P14920
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Resource-Q anion exchange column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex
-
Rattus norvegicus
-
midbrain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-serine + H2O + O2
-
Rattus norvegicus 2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
?
D-serine + H2O + O2
-
Homo sapiens 2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
D-amino acid oxidase
-
Rattus norvegicus
D-amino acid oxidase
-
Homo sapiens
DAAO
-
Rattus norvegicus
DAAO
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Rattus norvegicus
FAD
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00091
-
-
Homo sapiens 5-methylpyrazole-3-carboxylic acid