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Literature summary for 1.4.3.3 extracted from
- Physiological functions of D-amino acid oxidases: from yeast to humans (2007), Cell. Mol. Life Sci., 64, 1373-1394.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| in complex with benzoate | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.2 | - |
D-alanine | apparent value, at 25°C | Cyprinus carpio |  |
| 1 | - |
D-alanine | apparent value, at 25°C | Rhodotorula toruloides | |
| 1.3 | - |
D-alanine | apparent value, at 25°C | Homo sapiens | |
| 1.7 | - |
D-alanine | apparent value, at 25°C | Sus scrofa | |
| 4.3 | - |
D-alanine | apparent value, at 25°C | [Candida] boidinii | |
| 7 | - |
D-alanine | apparent value, at 25°C | Trigonopsis variabilis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| peroxisome | - |
Rhodotorula toruloides | 5777 | - |
| peroxisome | - |
Cyprinus carpio | 5777 | - |
| peroxisome | - |
Rattus norvegicus | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40076 | - |
2 * 40076, estimated from amino acid sequence | Rhodotorula toruloides |
| 80150 | - |
estimated from amino acid sequence | Rhodotorula toruloides |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Chlorella vulgaris | - |
- |
- |
| Cyprinus carpio | Q6TGN2 | - |
- |
| Homo sapiens | P14920 | - |
- |
| Mus musculus | P18894 | - |
- |
| Rattus norvegicus | O35078 | - |
- |
| Rhodotorula toruloides | P80324 | formerly Rhodotorula gracilis | - |
| Sus scrofa | P00371 | - |
- |
| Trigonopsis variabilis | Q99042 | - |
- |
| [Candida] boidinii | Q9HGY3 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| hepatocyte | - |
Rattus norvegicus | - |
| hepatopancreas | - |
Cyprinus carpio | - |
| intestine | - |
Cyprinus carpio | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Cyprinus carpio | - |
| kidney | - |
Sus scrofa | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| leukocyte | - |
Homo sapiens | - |
| skeletal muscle | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cephalosporin C + H2O + O2 | - |
Trigonopsis variabilis | 7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2 | - |
? | |
| cephalosporin C + H2O + O2 | - |
Rhodotorula toruloides | 7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2 | - |
? | |
| cephalosporin C + H2O + O2 | - |
Cyprinus carpio | 7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2 | - |
? | |
| cephalosporin C + H2O + O2 | - |
Sus scrofa | 7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2 | - |
? | |
| cephalosporin C + H2O + O2 | - |
Homo sapiens | 7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2 | - |
? | |
| D-alanine + H2O + O2 | - |
Trigonopsis variabilis | pyruvate + NH3 + H2O2 | - |
? | |
| D-alanine + H2O + O2 | - |
[Candida] boidinii | pyruvate + NH3 + H2O2 | - |
? | |
| D-alanine + H2O + O2 | - |
Rhodotorula toruloides | pyruvate + NH3 + H2O2 | - |
? | |
| D-alanine + H2O + O2 | - |
Mus musculus | pyruvate + NH3 + H2O2 | - |
? | |
| D-alanine + H2O + O2 | - |
Sus scrofa | pyruvate + NH3 + H2O2 | - |
? | |
| D-alanine + H2O + O2 | - |
Homo sapiens | pyruvate + NH3 + H2O2 | - |
? | |
| D-alanine + H2O + O2 | best substrate | Cyprinus carpio | pyruvate + NH3 + H2O2 | - |
? | |
| D-leucine + H2O + O2 | best substrate | Chlorella vulgaris | 4-methyl-2-oxopentanoic acid + NH3 + H2O2 | - |
? | |
| D-methionine + H2O + O2 | - |
Sus scrofa | 4-methylthio-2-oxobutanoic acid + NH3 + H2O2 | - |
? | |
| D-methionine + H2O + O2 | best substrate | Trigonopsis variabilis | 4-methylthio-2-oxobutanoic acid + NH3 + H2O2 | - |
? | |
| D-methionine + H2O + O2 | best substrate | [Candida] boidinii | 4-methylthio-2-oxobutanoic acid + NH3 + H2O2 | - |
? | |
| D-naphthylalanine + H2O + O2 | - |
Rhodotorula toruloides | naphthylpyruvate + NH3 + H2O2 | - |
? | |
| D-phenylalanine + H2O + O2 | - |
Trigonopsis variabilis | phenylpyruvate + NH3 + H2O2 | - |
? | |
| D-phenylalanine + H2O + O2 | - |
Rhodotorula toruloides | phenylpyruvate + NH3 + H2O2 | - |
? | |
| D-proline + H2O + O2 | - |
Cyprinus carpio | 2-oxopentanoic acid + NH3 + H2O2 | - |
? | |
| D-proline + H2O + O2 | best substrate | Sus scrofa | 2-oxopentanoate + NH3 + H2O2 | - |
? | |
| D-proline + H2O + O2 | best substrate | Homo sapiens | 2-oxopentanoate + NH3 + H2O2 | - |
? | |
| D-serine + H2O + O2 | - |
[Candida] boidinii | 2-oxo-3-hydroxypropionic acid + NH3 + H2O2 | - |
? | |
| D-serine + H2O + O2 | - |
Homo sapiens | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
| D-tryptophan + H2O + O2 | - |
Trigonopsis variabilis | indol-3-pyruvic acid + NH3 + H2O2 | - |
? | |
| D-tryptophan + H2O + O2 | - |
Rhodotorula toruloides | indol-3-pyruvic acid + NH3 + H2O2 | - |
? | |
| D-valine + H2O + O2 | - |
Cyprinus carpio | alpha-ketoisovaleric acid + NH3 + H2O2 | - |
? | |
| D-valine + H2O + O2 | best substrate | Rhodotorula toruloides | alpha-ketoisovaleric acid + NH3 + H2O2 | - |
? | |
| L-DOPA + H2O + O2 | - |
Homo sapiens | 3,4-dihydroxyphenylpyruvate + NH3 + H2O2 | - |
? | |
| additional information | the enzyme exhibits very low activity towards basic amino acids, and it does not oxidize those with an acidic side chain | Sus scrofa | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | x-ray crystallography | Homo sapiens |
| homodimer | 2 * 40076, estimated from amino acid sequence | Rhodotorula toruloides |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| D-amino acid oxidase | - |
Chlorella vulgaris |
| D-amino acid oxidase | - |
Trigonopsis variabilis |
| D-amino acid oxidase | - |
[Candida] boidinii |
| D-amino acid oxidase | - |
Rhodotorula toruloides |
| D-amino acid oxidase | - |
Mus musculus |
| D-amino acid oxidase | - |
Cyprinus carpio |
| D-amino acid oxidase | - |
Sus scrofa |
| D-amino acid oxidase | - |
Homo sapiens |
| D-amino acid oxidase | - |
Rattus norvegicus |
| DAAO | - |
Chlorella vulgaris |
| DAAO | - |
Trigonopsis variabilis |
| DAAO | - |
[Candida] boidinii |
| DAAO | - |
Rhodotorula toruloides |
| DAAO | - |
Mus musculus |
| DAAO | - |
Cyprinus carpio |
| DAAO | - |
Sus scrofa |
| DAAO | - |
Homo sapiens |
| DAAO | - |
Rattus norvegicus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 5.2 | - |
D-alanine | apparent value, at 25°C | Homo sapiens | |
| 7.3 | - |
D-alanine | apparent value, at 25°C | Sus scrofa | |
| 46 | - |
D-alanine | apparent value, at 25°C | Trigonopsis variabilis | |
| 80 | - |
D-alanine | apparent value, at 25°C | [Candida] boidinii | |
| 85 | - |
D-alanine | apparent value, at 25°C | Rhodotorula toruloides | |
| 95 | - |
D-alanine | apparent value, at 25°C | Cyprinus carpio | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | FAD-dependent flavoenzyme | Chlorella vulgaris | |
| FAD | FAD-dependent flavoenzyme | Trigonopsis variabilis | |
| FAD | FAD-dependent flavoenzyme | [Candida] boidinii | |
| FAD | FAD-dependent flavoenzyme | Rhodotorula toruloides | |
| FAD | FAD-dependent flavoenzyme | Mus musculus | |
| FAD | FAD-dependent flavoenzyme | Cyprinus carpio | |
| FAD | FAD-dependent flavoenzyme | Sus scrofa | |
| FAD | FAD-dependent flavoenzyme | Homo sapiens | |
| FAD | FAD-dependent flavoenzyme | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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