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Literature summary for 1.4.3.3 extracted from

  • Sparey, T.; Abeywickrema, P.; Almond, S.; Brandon, N.; Byrne, N.; Campbell, A.; Hutson, P.H.; Jacobson, M.; Jones, B.; Munshi, S.; Pascarella, D.; Pike, A.; Prasad, G.S.; Sachs, N.; Sakatis, M.; Sardana, V.; Venkatraman, S.; Young, M.B.
    The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors (2008), Bioorg. Med. Chem. Lett., 18, 3386-3391.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,4-dihydropyrrolo[3,2-c]pyrazole-5-carboxylic acid
-
Homo sapiens
1H-indole-2-carboxylic acid
-
Homo sapiens
1H-pyrrole-2-carboxylic acid
-
Homo sapiens
2,3-dimethyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
Homo sapiens
2-(2,4-dichlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
Homo sapiens
2-(3-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
Homo sapiens
2-(4-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
Homo sapiens
2-chloro-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
Homo sapiens
2-chloro-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
Homo sapiens
2-phenyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
Homo sapiens
3-(3-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
Homo sapiens
3-(4-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
Homo sapiens
3-(hydroxymethyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
Homo sapiens
3-chloro-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
Homo sapiens
3-cyano-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
Homo sapiens
3-pyridin-3-yl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
Homo sapiens
4,5-dichlorofuran-2-carboxylic acid
-
Homo sapiens
4-[2-(4-chlorophenyl)ethyl]-1H-pyrrole-3-carboxylic acid
-
Homo sapiens
4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
Homo sapiens
4H-pyrrolo[2,3-d][1,3]oxazole-5-carboxylic acid
-
Homo sapiens
4H-pyrrolo[2,3-d][1,3]thiazole-5-carboxylic acid
-
Homo sapiens
4H-pyrrolo[3,2-d][1,3]thiazole-5-carboxylic acid
-
Homo sapiens
4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
Homo sapiens
6-chloro-1,2-benzisoxazol-3-ol
-
Homo sapiens
6H-thieno[2,3-b]pyrrole-5-carboxylic acid
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14920
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-serine + H2O + O2
-
Homo sapiens 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
D-amino acid oxidase
-
Homo sapiens
DAO
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000141
-
-
Homo sapiens 4H-furo[3,2-b]pyrrole-5-carboxylic acid
0.000238
-
-
Homo sapiens 4-[2-(4-chlorophenyl)ethyl]-1H-pyrrole-3-carboxylic acid
0.000245
-
-
Homo sapiens 4H-thieno[3,2-b]pyrrole-5-carboxylic acid
0.000269
-
-
Homo sapiens 6H-thieno[2,3-b]pyrrole-5-carboxylic acid
0.000343
-
-
Homo sapiens 4,5-dichlorofuran-2-carboxylic acid
0.000507
-
-
Homo sapiens 6-chloro-1,2-benzisoxazol-3-ol
0.000516
-
-
Homo sapiens 4H-pyrrolo[2,3-d][1,3]thiazole-5-carboxylic acid
0.000745
-
-
Homo sapiens 1H-indole-2-carboxylic acid
0.001153
-
-
Homo sapiens 3-cyano-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
0.001426
-
-
Homo sapiens 3-chloro-4H-furo[3,2-b]pyrrole-5-carboxylic acid
0.004204
-
-
Homo sapiens 4H-pyrrolo[3,2-d][1,3]thiazole-5-carboxylic acid
0.005
-
IC50 above 0.005 mM Homo sapiens 3-pyridin-3-yl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
0.005
-
IC50 above 0.005 mM Homo sapiens 2-chloro-4H-furo[3,2-b]pyrrole-5-carboxylic acid
0.005
-
IC50 above 0.005 mM Homo sapiens 2-chloro-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
0.005
-
IC50 above 0.005 mM Homo sapiens 2-phenyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
0.005
-
IC50 above 0.005 mM Homo sapiens 3-(hydroxymethyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
0.005
-
IC50 above 0.005 mM Homo sapiens 3-(3-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
0.005
-
IC50 above 0.005 mM Homo sapiens 3-(4-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
0.005
-
IC50 above 0.005 mM Homo sapiens 4H-pyrrolo[2,3-d][1,3]oxazole-5-carboxylic acid
0.005
-
IC50 above 0.005 mM Homo sapiens 1H-pyrrole-2-carboxylic acid
0.005
-
IC50 above 0.005 mM Homo sapiens 2-(3-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
0.005
-
IC50 above 0.005 mM Homo sapiens 2-(4-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
0.005
-
IC50 above 0.005 mM Homo sapiens 2-(2,4-dichlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
0.005
-
IC50 above 0.005 mM Homo sapiens 2,3-dimethyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
0.005
-
IC50 above 0.005 mM Homo sapiens 1,4-dihydropyrrolo[3,2-c]pyrazole-5-carboxylic acid