Literature summary for 1.4.3.23 extracted from

Howard-Jones, A.R.; Walsh, C.T.
Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD (2005), Biochemistry, 44, 15652-15663.

Search for more literature for 1.4.3.23

Cloned(Commentary)

Cloned (Comment)	Organism
expression of N-His6-tagged RebO in Escherichia coli	Lentzea aerocolonigenes

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
56000	-	x * 56000, SDS-PAGE	Lentzea aerocolonigenes

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
7-chloro-L-tryptophan + O2	Lentzea aerocolonigenes	rebeccamycin biosynthetic pathway	2-imino-3-(7-chloroindol-3-yl)propanoate + H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Lentzea aerocolonigenes	Q8KHS0	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Lentzea aerocolonigenes

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7-chloro-L-tryptophan + O2	-	Lentzea aerocolonigenes	2-imino-3-(7-chloroindol-3-yl)propanoate + H2O2	-	?
7-chloro-L-tryptophan + O2	rebeccamycin biosynthetic pathway	Lentzea aerocolonigenes	2-imino-3-(7-chloroindol-3-yl)propanoate + H2O2	-	?

Subunits

Subunits	Comment	Organism
?	x * 56000, SDS-PAGE	Lentzea aerocolonigenes

Synonyms

Synonyms	Comment	Organism
RebO	-	Lentzea aerocolonigenes

Cofactor

Cofactor	Comment	Organism	Structure
FAD	noncovalently bound, FAD occupancy at 70%	Lentzea aerocolonigenes

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Release 2023.1 (January 2023)