Application | Comment | Organism |
---|---|---|
medicine | VAP-1 might be a target for anti-inflammatory drug therapy because of its role in leukocyte adhesion to endothelium | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in CHO cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R,2S)-2-(1-methylhydrazino)-1-phenylbutan-1-ol | - |
Homo sapiens | |
(1R,2S)-2-(1-methylhydrazino)-1-phenylpentan-1-ol | - |
Homo sapiens | |
(1R,2S)-2-(1-methylhydrazino)-1-phenylpropan-1-ol | - |
Homo sapiens | |
1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-(1-methylhydrazino)-ethanol | - |
Homo sapiens | |
1-(2-(3-chlorophenyl)-2-methoxyethyl)-1-methylhydrazine | - |
Homo sapiens | |
1-(2-chlorophenyl)-2-(1-methylhydrazino)ethanol | - |
Homo sapiens | |
1-(2-phenylpropyl)hydrazine | - |
Homo sapiens | |
1-(3-methoxyphenyl)-2-(1-methylhydrazino)ethanol | - |
Homo sapiens | |
1-(4-chlorophenyl)-2-(1-methylhydrazino)ethanol | - |
Homo sapiens | |
1-(4-fluorophenyl)-2-(1-methylhydrazino)ethanol | - |
Homo sapiens | |
1-(4-methoxyphenyl)-2-(1-methylhydrazino)ethanol | - |
Homo sapiens | |
1-benzyl-1-methylhydrazine | - |
Homo sapiens | |
1-ethyl-1-(2-phenylethyl)hydrazine | - |
Homo sapiens | |
1-ethyl-1-[2-(3,4,5-trimethoxyphenyl)ethyl]hydrazine | - |
Homo sapiens | |
1-ethyl-1-[2-(4-methoxyphenyl)ethyl]hydrazine | - |
Homo sapiens | |
1-isobutyl-1-(2-phenylethyl)hydrazine | - |
Homo sapiens | |
1-isobutyl-1-[2-(4-methoxyphenyl)ethyl]hydrazine | - |
Homo sapiens | |
1-methyl-1-(2-phenylethyl)hydrazine | - |
Homo sapiens | |
1-methyl-1-(2-phenylpropyl)hydrazine | - |
Homo sapiens | |
1-methyl-1-(3-phenylpropyl)hydrazine | - |
Homo sapiens | |
1-[2-(2,3,4-trimethoxyphenyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-(2,5-dimethoxyphenyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-(2-chlorophenyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-(2-fluorophenyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-(2-methoxyphenyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-(3,4,5-trimethoxyphenyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-(3,4-dimethoxyphenyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-(3-chlorophenyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-(3-fluorophenyl)-2-methoxyethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-(3-methoxyphenyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-(4-chlorophenyl)-2-methoxyethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-(4-chlorophenyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-(4-fluorophenyl)-2-methoxyethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-(4-fluorophenyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-(4-methoxyphenyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-benzyloxy-2-(4-methoxyphenyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-methoxy-1-(3-tolyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-methoxy-1-(4-methoxyphenyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-methoxy-2-(1-naphthyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-methoxy-2-(2,3,4-trimethoxyphenyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-methoxy-2-(2-naphthyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
1-[2-methoxy-2-(3-methoxyphenyl)ethyl]-1-methylhydrazine | - |
Homo sapiens | |
2,2-dimethyl-2-(1-methylhydrazino)-1-phenylethanol | - |
Homo sapiens | |
2-(1-isobutylhydrazino)-1-phenylethanol | - |
Homo sapiens | |
2-(1-methylhydrazino)-1-(2,3,4-trimethoxyphenyl)ethanol | - |
Homo sapiens | |
2-(1-methylhydrazino)-1-(2-naphthyl)ethanol | - |
Homo sapiens | |
2-(1-methylhydrazino)-1-phenylethanol | - |
Homo sapiens | |
2-(4-methoxyphenyl)-1-(1-methylhydrazino)-2-propanol | - |
Homo sapiens | |
2-hydrazino-1-(3-methoxyphenyl)ethanol | - |
Homo sapiens | |
2-hydrazino-1-(4-methoxyphenyl)ethanol | - |
Homo sapiens | |
2-hydrazino-1-phenylethanol | - |
Homo sapiens | |
additional information | synthesis and in vitro activities of a series of VAP-1 selective inhibitors, molecular dynamics simulations and docking studies, pIC50 values, overview. Movements of Met211, Ser496, and especially Leu469 can enlarge the ligand-binding pocket, allowing larger ligands than those seen in the crystal structures to bind. Three-dimensional quantitative structure-activity relationship models for VAP-1 in comparison to MAOs, overview | Homo sapiens | |
Phenelzine | - |
Homo sapiens | |
Semicarbazide | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | VAP-1/SSAOs convert amines into aldehydes. SSAOs are distinct from the mammalian monoamine oxidases, MAOs, but their substrate specificities are partly overlapping | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16853 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzylamine + H2O + O2 | - |
Homo sapiens | benzaldehyde + NH3 + H2O2 | - |
? | |
additional information | VAP-1/SSAOs convert amines into aldehydes. SSAOs are distinct from the mammalian monoamine oxidases, MAOs, but their substrate specificities are partly overlapping | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | VAP-1 belongs to the semicarbazide-sensitive amine oxidases, SSAOs | Homo sapiens |
semicarbazide-sensitive amine oxidase | - |
Homo sapiens |
SSAO | - |
Homo sapiens |
VAP-1 | - |
Homo sapiens |
vascular adhesion protein-1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |