Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.4.3.21 extracted from

  • Bertini, V.; Buffoni, F.; Ignesti, G.; Picci, N.; Trombino, S.; Iemma, F.; Alfei, S.; Pocci, M.; Lucchesini, F.; De Munno, A.
    Alkylamino derivatives of 4-aminomethylpyridine as inhibitors of copper-containing amine oxidases (2005), J. Med. Chem., 48, 664-670.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride
-
Ogataea angusta
1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride
-
Pisum sativum
1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride
-
Sus scrofa
1-[3,5-bis(ethylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
-
Sus scrofa
1-[3,5-bis(tert-butylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
-
Sus scrofa
1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
-
Sus scrofa
2-ethylaminobenzylamine dihydrochloride
-
Ogataea angusta
2-ethylaminobenzylamine dihydrochloride
-
Pisum sativum
2-ethylaminobenzylamine dihydrochloride
-
Sus scrofa
2-methylaminobenzylamine dihydrochloride
-
Ogataea angusta
2-methylaminobenzylamine dihydrochloride
-
Pisum sativum
2-methylaminobenzylamine dihydrochloride
-
Sus scrofa
3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride
-
Sus scrofa
3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate
-
Ogataea angusta
3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate
-
Sus scrofa
3-amino-4-aminomethylpyridine dihydrochloride
-
Sus scrofa
3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
Ogataea angusta
3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
Pisum sativum
3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
Sus scrofa
3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
Ogataea angusta
3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
Sus scrofa
3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
Ogataea angusta
3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
Pisum sativum
3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
Sus scrofa
3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate
-
Ogataea angusta
3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate
-
Sus scrofa
3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate
-
Ogataea angusta
3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate
-
Sus scrofa
3-ethylamino-4-aminomethylpyridine dihydrochloride
-
Ogataea angusta
3-ethylamino-4-aminomethylpyridine dihydrochloride
-
Pisum sativum
3-ethylamino-4-aminomethylpyridine dihydrochloride
-
Sus scrofa
3-methylamino-4-aminomethylpyridine dihydrochloride
-
Ogataea angusta
3-methylamino-4-aminomethylpyridine dihydrochloride
-
Pisum sativum
3-methylamino-4-aminomethylpyridine dihydrochloride
-
Sus scrofa
3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride
-
Ogataea angusta
3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride
-
Sus scrofa
4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride
-
Sus scrofa
4-(aminomethyl)-N,N'-bis(1-methylethyl)pyridine-3,5-diamine dihydrochloride
-
Sus scrofa
4-(aminomethyl)-N,N'-dibutylpyridine-3,5-diamine dihydrochloride
-
Sus scrofa
4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
-
Ogataea angusta
4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
-
Pisum sativum
4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
-
Sus scrofa
4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
-
Ogataea angusta
4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
-
Pisum sativum
4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
-
Sus scrofa
4-(aminomethyl)-N-methylpyridine-3,5-diamine dihydrochloride
-
Sus scrofa
alkylamino derivatives of 4-aminomethylpyridine
-
Ogataea angusta

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.016
-
4-aminomethylpyridine dihydrochloride
-
Sus scrofa
0.124
-
benzylamine
-
Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
copper
-
Ogataea angusta

Organism

Organism UniProt Comment Textmining
Ogataea angusta P12807
-
-
Pisum sativum Q42432 fragment
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
seedling
-
Pisum sativum
-
serum
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminomethylpyridine dihydrochloride + H2O + O2 45% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (beta-phenylethylamine, 1 mM) for various amine oxidases Ogataea angusta ?
-
?
4-aminomethylpyridine dihydrochloride + H2O + O2 87% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (benzylamine, 1 mM) for various amine oxidases Sus scrofa ?
-
?
4-aminomethylpyridine dihydrochloride + H2O + O2 less than 0.1% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (putrescine, 1 mM) for various amine oxidases Pisum sativum ?
-
?
benzylamine + H2O + O2
-
Sus scrofa benzaldehyde + NH3 + H2O2
-
?
beta-phenylethylamine + H2O + O2
-
Ogataea angusta beta-phenylethanal + NH3 + H2O2
-
?
putrescine + H2O + O2
-
Pisum sativum ?
-
?

Synonyms

Synonyms Comment Organism
BAO
-
Sus scrofa
benzylamine oxidase
-
Sus scrofa
copper-containing amine oxidase
-
Pisum sativum
Hansenula polymorpha amine oxidase
-
Ogataea angusta
HPAO
-
Ogataea angusta
PSAO
-
Pisum sativum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
above 0.1 for 2-methylaminobenzylamine dihydrochloride, 3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate, and 2-ethylaminobenzylamine dihydrochloride, above 0.0001 for 3d Sus scrofa additional information
additional information
-
above 0.1 mM for 2-methylaminobenzylamine dihydrochloride and 2-ethylaminobenzylamine dihydrochloride Pisum sativum additional information
additional information
-
above 1.0 mM for 1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride, 3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride, 3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate, 3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate, 3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate, and above 0.3 mM for 3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate Ogataea angusta additional information
0.00002
-
-
Sus scrofa 4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
0.00013
-
-
Sus scrofa 1-[3,5-bis(ethylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
0.00015
-
-
Sus scrofa 4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride
0.00017
-
-
Sus scrofa 1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride
0.00044
-
-
Sus scrofa 4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
0.00071
-
-
Pisum sativum 3-methylamino-4-aminomethylpyridine dihydrochloride
0.0016
-
-
Sus scrofa 1-[3,5-bis(tert-butylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
0.0017
-
-
Sus scrofa 4-(aminomethyl)-N-methylpyridine-3,5-diamine dihydrochloride
0.002
-
-
Sus scrofa 3-ethylamino-4-aminomethylpyridine dihydrochloride
0.0032
-
-
Sus scrofa 3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride
0.005
-
-
Sus scrofa 1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
0.0056
-
-
Sus scrofa 3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
0.0056
-
-
Sus scrofa 3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate
0.008
-
-
Sus scrofa 3-methylamino-4-aminomethylpyridine dihydrochloride
0.0093
-
-
Pisum sativum 3-ethylamino-4-aminomethylpyridine dihydrochloride
0.016
-
-
Sus scrofa 3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate
0.016
-
-
Sus scrofa 3-amino-4-aminomethylpyridine dihydrochloride
0.017
-
-
Pisum sativum 4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
0.053
-
-
Ogataea angusta 3-methylamino-4-aminomethylpyridine dihydrochloride
0.055
-
-
Pisum sativum 4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
0.079
-
-
Sus scrofa 3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
0.087
-
-
Ogataea angusta 3-ethylamino-4-aminomethylpyridine dihydrochloride
0.1
-
-
Ogataea angusta 4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
0.1
-
-
Sus scrofa 3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride
0.1
-
-
Sus scrofa 3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate
0.33
-
-
Pisum sativum 1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride
0.35
-
-
Ogataea angusta 4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
0.35
-
-
Sus scrofa 4-(aminomethyl)-N,N'-dibutylpyridine-3,5-diamine dihydrochloride
0.54
-
-
Ogataea angusta 3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
0.7
-
-
Ogataea angusta 3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate
0.75
-
-
Ogataea angusta 2-methylaminobenzylamine dihydrochloride
0.89
-
-
Pisum sativum 3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
1
-
-
Pisum sativum 3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
1.5
-
-
Ogataea angusta 2-ethylaminobenzylamine dihydrochloride