Inhibitors | Comment | Organism | Structure |
---|---|---|---|
m-chlorobenzoate | LAO inhibitor, does not inhibit the degradation of fibrinogen | Gloydius blomhoffii | |
o-aminobenzoic acid | LAO inhibitor, slightly inhibiting the degradation of fibrinogen | Gloydius blomhoffii |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
x * 60000, SDS-PAGE | Gloydius blomhoffii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Gloydius blomhoffii | the LAO-containing fraction inhibits coagulation factor IX, and it prolongs the APTT, PT and fibrinogen clotting time and cleaves the Aalpha-chain of fibrinogen probably due to the presence of traces of a metalloproteinase in the fraction, overview. The mechanism for the anticoagulant activity of M-LAO fraction is not due to binding to factor IX. The fibrinogenolytic activity of the M-LAO fraction is independent of either LAO enzymatic activity or generated hydrogen peroxide | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gloydius blomhoffii | Q90W54 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
flavoprotein | - |
Gloydius blomhoffii |
Purification (Comment) | Organism |
---|---|
native enzyme by gel filtration, cation and anion exchange chromatography, and hydroxyapatite chromatography | Gloydius blomhoffii |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DL-norleucine + H2O + O2 | - |
Gloydius blomhoffii | 2-oxocaproate + NH3 + H2O2 | - |
? | |
additional information | the LAO-containing fraction inhibits coagulation factor IX, and it prolongs the APTT, PT and fibrinogen clotting time and cleaves the Aalpha-chain of fibrinogen probably due to the presence of traces of a metalloproteinase in the fraction, overview. The mechanism for the anticoagulant activity of M-LAO fraction is not due to binding to factor IX. The fibrinogenolytic activity of the M-LAO fraction is independent of either LAO enzymatic activity or generated hydrogen peroxide | Gloydius blomhoffii | ? | - |
? | |
additional information | L-amino acid oxidase is a dimeric glycosylated flavoenzyme that catalyses the oxidative deamination of an L-amino acid substrate to a 2-oxo acid along with the production of ammonia and hydrogen peroxide | Gloydius blomhoffii | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 60000, SDS-PAGE | Gloydius blomhoffii |
Synonyms | Comment | Organism |
---|---|---|
M-LAO | - |
Gloydius blomhoffii |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Gloydius blomhoffii |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Gloydius blomhoffii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
flavin | LAO is a flavoenzyme | Gloydius blomhoffii |