Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptidyl-L-lysyl-peptide + O2 + H2O | Homo sapiens | - |
peptidyl-allysyl-peptide + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
RCC-10 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptidyl-L-lysyl-peptide + O2 + H2O | - |
Homo sapiens | peptidyl-allysyl-peptide + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LOX | - |
Homo sapiens |
LOX-like 2 | - |
Homo sapiens |
Loxl2 | - |
Homo sapiens |
lysyl oxidase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
lysyl-tyrosyl quinone | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | LOX and LOXL2 are induced 13 and 7.5fold, respectively, by hypoxia-inducible transcription factor-1alpha and hypoxia-inducible transcription factor-2beta | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia, thereby inducing epithelial to mesenchymal transition | Homo sapiens |