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Literature summary for 1.4.3.13 extracted from

  • Schietke, R.; Warnecke, C.; Wacker, I.; Sch๖del, J.; Mole, D.; Campean, V.; Amann, K.; Goppelt-Struebe, M.; Behrens, J.; Eckardt, K.; Wiesener, M.
    The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: Insights into cellular transformation processes mediated by HIF-1 (2010), J. Biol. Chem., 285, 6658-6669.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptidyl-L-lysyl-peptide + O2 + H2O Homo sapiens
-
peptidyl-allysyl-peptide + NH3 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
RCC-10 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptidyl-L-lysyl-peptide + O2 + H2O
-
Homo sapiens peptidyl-allysyl-peptide + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
LOX
-
Homo sapiens
LOX-like 2
-
Homo sapiens
Loxl2
-
Homo sapiens
lysyl oxidase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
lysyl-tyrosyl quinone
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens LOX and LOXL2 are induced 13 and 7.5fold, respectively, by hypoxia-inducible transcription factor-1alpha and hypoxia-inducible transcription factor-2beta up

General Information

General Information Comment Organism
physiological function the lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia, thereby inducing epithelial to mesenchymal transition Homo sapiens