Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | LOX is secreted as a glycosylated proenzyme with a MW of 50 kDa, and is proteolytically processed by procollagen C proteinase, i.e. bone morphogenic protein-1, into a mature, biologically active MW 32 kDa form | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | LOX is copper-dependent | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | LOX is a copper-dependent amine oxidase that initiates the covalent cross-linking of collagen and elastin side chains and thereby contributes to extracellular matrix integrity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
proteolytic modification | LOX is secreted as a glycosylated proenzyme with a MW of 50 kDa, and is proteolytically processed by procollagen C proteinase, i.e. bone morphogenic protein-1, into a mature, biologically active MW 32 kDa form | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | - |
Homo sapiens | - |
lens | determination of LOX activity and expression in donor ocular tissues | Homo sapiens | - |
retina | - |
Homo sapiens | - |
retinal pigment epithelium | determination of LOX activity and expression in donor ocular tissues | Homo sapiens | - |
vitreous chamber | determination of LOX activity and expression in donor ocular tissues | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.2 | - |
about, retina | Homo sapiens |
0.4 | - |
about, lens | Homo sapiens |
1.1 | - |
about, iris/ciliary body | Homo sapiens |
1.2 | - |
about, vitreous ocular tissue | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | LOX is a copper-dependent amine oxidase that initiates the covalent cross-linking of collagen and elastin side chains and thereby contributes to extracellular matrix integrity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LOX | - |
Homo sapiens |
lysyl oxidase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | reduced enzyme expression is involved in the vitreous of proliferative diabetic retinopathy, PDR, and rhegmatogenous retinal detachment, RRD | Homo sapiens |
physiological function | LOX cross-links the side chain of collagen and elastin and thereby contributes to extracellular matrix integrity | Homo sapiens |