Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.4.3.13 extracted from

  • Coral, K.; Angayarkanni, N.; Madhavan, J.; Bharathselvi, M.; Ramakrishnan, S.; Nandi, K.; Rishi, P.; Kasinathan, N.; Krishnakumar, S.
    Lysyl oxidase activity in the ocular tissues and the role of LOX in proliferative diabetic retinopathy and rhegmatogenous retinal detachment (2008), Invest. Ophthalmol. Vis. Sci., 49, 4746-4752.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular LOX is secreted as a glycosylated proenzyme with a MW of 50 kDa, and is proteolytically processed by procollagen C proteinase, i.e. bone morphogenic protein-1, into a mature, biologically active MW 32 kDa form Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ LOX is copper-dependent Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens LOX is a copper-dependent amine oxidase that initiates the covalent cross-linking of collagen and elastin side chains and thereby contributes to extracellular matrix integrity ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens
proteolytic modification LOX is secreted as a glycosylated proenzyme with a MW of 50 kDa, and is proteolytically processed by procollagen C proteinase, i.e. bone morphogenic protein-1, into a mature, biologically active MW 32 kDa form Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
eye
-
Homo sapiens
-
lens determination of LOX activity and expression in donor ocular tissues Homo sapiens
-
retina
-
Homo sapiens
-
retinal pigment epithelium determination of LOX activity and expression in donor ocular tissues Homo sapiens
-
vitreous chamber determination of LOX activity and expression in donor ocular tissues Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.2
-
about, retina Homo sapiens
0.4
-
about, lens Homo sapiens
1.1
-
about, iris/ciliary body Homo sapiens
1.2
-
about, vitreous ocular tissue Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information LOX is a copper-dependent amine oxidase that initiates the covalent cross-linking of collagen and elastin side chains and thereby contributes to extracellular matrix integrity Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
LOX
-
Homo sapiens
lysyl oxidase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction reduced enzyme expression is involved in the vitreous of proliferative diabetic retinopathy, PDR, and rhegmatogenous retinal detachment, RRD Homo sapiens
physiological function LOX cross-links the side chain of collagen and elastin and thereby contributes to extracellular matrix integrity Homo sapiens