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Literature summary for 1.4.3.13 extracted from
- Regulation of elastin promoter by lysyl oxidase and growth factors: cross control of lysyl oxidase on TGF-beta1 effects (2007), Matrix Biol., 26, 494-505.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | LOX regulates also the promoter of elastin und collagen III, treatment with tumor growth factor-beta1 and CTGF abolishes completely the activation induced by LOX | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-aminopropanenitrile | irreversible LOX inhibitor | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| collagen III + O2 + H2O | Homo sapiens | - |
allysyl-collagen III + NH3 + H2O2 | - |
? | |
| elastin + H2O + O2 | Homo sapiens | - |
allysyl-elastin + NH3 + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293T cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| collagen III + O2 + H2O | - |
Homo sapiens | allysyl-collagen III + NH3 + H2O2 | - |
? | |
| elastin + H2O + O2 | - |
Homo sapiens | allysyl-elastin + NH3 + H2O2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LOX | - |
Homo sapiens |
| lysyl oxidase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| lysyl-tyrosyl-quinone | - |
Homo sapiens | |
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