Inhibitors | Comment | Organism | Structure |
---|---|---|---|
beta-aminopropionitrile | - |
Rattus norvegicus | |
beta-aminopropionitrile | - |
Sus scrofa | |
homocysteine | down-regulates LOX mRNA and transcriptional activity | Rattus norvegicus | |
homocysteine | down-regulates LOX mRNA and transcriptional activity | Sus scrofa | |
homocysteine thiolactone | - |
Rattus norvegicus | |
homocysteine thiolactone | - |
Sus scrofa | |
low-density lipoprotein | - |
Rattus norvegicus | |
low-density lipoprotein | - |
Sus scrofa | |
additional information | hypercholesterolemia down-regulates LOX expression and activity | Rattus norvegicus | |
additional information | hypercholesterolemia down-regulates LOX expression and activity | Sus scrofa | |
tumor necrosis factor-alpha | inhibits LOX mRNA transcription and LOX activity | Rattus norvegicus | |
tumor necrosis factor-alpha | inhibits LOX mRNA transcription and LOX activity | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
cytosol | - |
Sus scrofa | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | required for activity | Rattus norvegicus | |
Cu2+ | required for activity | Sus scrofa |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32000 | - |
active enzyme, SDS-PAGE | Rattus norvegicus |
32000 | - |
active enzyme, SDS-PAGE | Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | LOX suffers different posttranslational modifications including signal peptide cleavage, glycosylation, copper incorporation and formation of the lysyl-tyrosyl-quinone cofactor | Rattus norvegicus |
additional information | LOX suffers different posttranslational modifications including signal peptide cleavage, glycosylation, copper incorporation and formation of the lysyl-tyrosyl-quinone cofactor | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | - |
Rattus norvegicus | - |
endothelial cell | - |
Sus scrofa | - |
vascular smooth muscle cell | - |
Rattus norvegicus | - |
vascular smooth muscle cell | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptidyl-L-lysyl-peptide + O2 + H2O | - |
Rattus norvegicus | peptidyl-allysyl-peptide + NH3 + H2O2 | - |
? | |
peptidyl-L-lysyl-peptide + O2 + H2O | - |
Sus scrofa | peptidyl-allysyl-peptide + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LOX | - |
Rattus norvegicus |
LOX | - |
Sus scrofa |
lysyl oxidase | - |
Rattus norvegicus |
lysyl oxidase | - |
Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
lysyl-tyrosyl-quinone | - |
Rattus norvegicus | |
lysyl-tyrosyl-quinone | - |
Sus scrofa |