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Literature summary for 1.4.3.13 extracted from

  • Alcudia, J.F.; Martinez-Gonzalez, J.; Guadall, A.; Gonzalez-Diez, M.; Badimon, L.; Rodriguez, C.
    Lysyl oxidase and endothelial dysfunction: mechanisms of lysyl oxidase down-regulation by pro-inflammatory cytokines (2008), Front. Biosci., 13, 2721-2727.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
beta-aminopropionitrile
-
Rattus norvegicus
beta-aminopropionitrile
-
Sus scrofa
homocysteine down-regulates LOX mRNA and transcriptional activity Rattus norvegicus
homocysteine down-regulates LOX mRNA and transcriptional activity Sus scrofa
homocysteine thiolactone
-
Rattus norvegicus
homocysteine thiolactone
-
Sus scrofa
low-density lipoprotein
-
Rattus norvegicus
low-density lipoprotein
-
Sus scrofa
additional information hypercholesterolemia down-regulates LOX expression and activity Rattus norvegicus
additional information hypercholesterolemia down-regulates LOX expression and activity Sus scrofa
tumor necrosis factor-alpha inhibits LOX mRNA transcription and LOX activity Rattus norvegicus
tumor necrosis factor-alpha inhibits LOX mRNA transcription and LOX activity Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-
cytosol
-
Sus scrofa 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ required for activity Rattus norvegicus
Cu2+ required for activity Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
active enzyme, SDS-PAGE Rattus norvegicus
32000
-
active enzyme, SDS-PAGE Sus scrofa

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information LOX suffers different posttranslational modifications including signal peptide cleavage, glycosylation, copper incorporation and formation of the lysyl-tyrosyl-quinone cofactor Rattus norvegicus
additional information LOX suffers different posttranslational modifications including signal peptide cleavage, glycosylation, copper incorporation and formation of the lysyl-tyrosyl-quinone cofactor Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
Rattus norvegicus
-
endothelial cell
-
Sus scrofa
-
vascular smooth muscle cell
-
Rattus norvegicus
-
vascular smooth muscle cell
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptidyl-L-lysyl-peptide + O2 + H2O
-
Rattus norvegicus peptidyl-allysyl-peptide + NH3 + H2O2
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
-
Sus scrofa peptidyl-allysyl-peptide + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
LOX
-
Rattus norvegicus
LOX
-
Sus scrofa
lysyl oxidase
-
Rattus norvegicus
lysyl oxidase
-
Sus scrofa

Cofactor

Cofactor Comment Organism Structure
lysyl-tyrosyl-quinone
-
Rattus norvegicus
lysyl-tyrosyl-quinone
-
Sus scrofa