Application | Comment | Organism |
---|---|---|
medicine | chronic inhalation of cadmium induces emphysema. Long-term Cd exposure induces inhibition of Cu-dependent lysyl oxidase and its substrates, by upregulation of Cu scavenging thiols in pulmonary fibroblasts. Downregulation of lysyl oxidase results from limitated Cu bioavailability as a central event contributing to Cd-induced extracellular matrix damage. Restoration of LO levels in Cd-insulted lung cells or tissues by replenishing Cu may have a protective or therapeutic effect on Cd-induced emphysema | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung fibroblast | fetal | Rattus norvegicus | - |