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Literature summary for 1.4.3.13 extracted from

  • Zhao, Y.; Gao, S.; Chou, I.N.; Toselli, P.; Stone, P.; Li, W.
    Inhibition of the expression of lysyl oxidase and its substrates in cadmium-resistant rat fetal lung fibroblasts (2006), Toxicol. Sci., 90, 478-489.
    View publication on PubMed

Application

Application Comment Organism
medicine chronic inhalation of cadmium induces emphysema. Long-term Cd exposure induces inhibition of Cu-dependent lysyl oxidase and its substrates, by upregulation of Cu scavenging thiols in pulmonary fibroblasts. Downregulation of lysyl oxidase results from limitated Cu bioavailability as a central event contributing to Cd-induced extracellular matrix damage. Restoration of LO levels in Cd-insulted lung cells or tissues by replenishing Cu may have a protective or therapeutic effect on Cd-induced emphysema Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
lung fibroblast fetal Rattus norvegicus
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