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Literature summary for 1.4.3.13 extracted from

  • Levene, C.I.; O'Shea, M.P.; Carrington, M.J.
    Protein lysine 6-oxidase (lysyl oxidase) cofactor: methoxatin (PQQ) or pyridoxal? (1988), Int. J. Biochem., 20, 1451-1456.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
pyridoxal derivative Gallus gallus
pyridoxal needed for biosynthesis of the enzyme Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
4-deoxypyridoxine pyridoxal analogue, 50% inhibition at 3 mM Gallus gallus
beta-aminopropionitrile
-
Gallus gallus
Isonicotinic acid hydrazide reversible, 61.8% of full activity restored by pyridoxal or 30.1% by pyrroloquinoline-quinone Gallus gallus
Semicarbazide reversible, 21.2% of full activity restored by pyridoxal or 10% by pyrroloquinoline-quinone Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+
-
Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
embryo
-

Source Tissue

Source Tissue Comment Organism Textmining
bone leg Gallus gallus
-
cartilage
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptidyl-L-hydroxylysyl-peptide + O2 + H2O part of tropocollagen and tropoelastin Gallus gallus peptidyl-L-2-amino-5-hydroxy-6-oxohexanoyl-peptide + NH3 + H2O2
-
?
peptidyl-L-lysyl-peptide + O2 + H2O part of tropocollagen and tropoelastin Gallus gallus peptidyl-L-allysyl-peptide + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
lysyl oxidase amine oxidase, oxidative deamination Gallus gallus