Application | Comment | Organism |
---|---|---|
synthesis | the enzyme is a useful biocatalyst for the kinetic resolution and dereacemization of amines | Microbacterium oxydans |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 cells | Microbacterium oxydans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cyclohexylamine + O2 + H2O | Microbacterium oxydans | 100% activity | cyclohexanone + NH3 + H2O2 | - |
? | |
cyclohexylamine + O2 + H2O | Microbacterium oxydans IH-35A | 100% activity | cyclohexanone + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Microbacterium oxydans | - |
- |
- |
Microbacterium oxydans IH-35A | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-2-heptylamine + O2 + H2O | 0.1% activity compared to cyclohexylamine | Microbacterium oxydans | heptan-2-one + NH3 + H2O2 | - |
? | |
(R)-2-heptylamine + O2 + H2O | 0.1% activity compared to cyclohexylamine | Microbacterium oxydans IH-35A | heptan-2-one + NH3 + H2O2 | - |
? | |
(S)-2-heptylamine + O2 + H2O | 25% activity compared to cyclohexylamine | Microbacterium oxydans | heptan-2-one + NH3 + H2O2 | - |
? | |
(S)-alpha-methylbenzylamine + O2 + H2O | 55% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
1-(4-chlorophenyl)ethanamine + O2 + H2O | 35% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
1-(4-fluorophenyl)ethanamine + O2 + H2O | 61% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
1-(4-methylphenyl)ethanamine + O2 + H2O | 5% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
1-(4-methylphenyl)methanamine + O2 + H2O | 1% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
1-(naphthalen-1-yl)ethanamine + O2 + H2O | 1% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
1-indanamine + O2 + H2O | 27% activity compared to cyclohexylamine | Microbacterium oxydans | 1-indanone + NH3 + H2O2 | - |
? | |
1-phenylethanamine + O2 + H2O | 48% activity compared to cyclohexylamine | Microbacterium oxydans | 1-phenylethanone + NH3 + H2O2 | - |
? | |
2-heptylamine + O2 + H2O | 24% activity compared to cyclohexylamine | Microbacterium oxydans | heptan-2-one + NH3 + H2O2 | - |
? | |
2-methylcyclohexanamine + O2 + H2O | 56% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
2-methylpropan-1-amine + O2 + H2O | 0.1% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
3-phenylpropan-1-amine + H2O + O2 | 7% activity compared to cyclohexylamine | Microbacterium oxydans | ? + NH3 + H2O2 | - |
? | |
3-phenylpropan-1-amine + H2O + O2 | 7% activity compared to cyclohexylamine | Microbacterium oxydans IH-35A | ? + NH3 + H2O2 | - |
? | |
4-methylcyclohexylamine + O2 + H2O | 133% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
4-methylpiperidine + O2 + H2O | 0.1% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
4-phenylbutan-2-amine + O2 + H2O | 12% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
5-methylhexan-2-amine + O2 + H2O | 9% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
6-amino-2-methylheptan-2-ol + O2 + H2O | 0.1% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
bicyclo[2.2.1]heptan-2-amine + O2 + H2O | 2% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
butan-2-amine + O2 + H2O | 3% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
cycloheptanamine + O2 + H2O | 75% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
cyclohexylamine + O2 + H2O | 100% activity | Microbacterium oxydans | cyclohexanone + NH3 + H2O2 | - |
? | |
cyclohexylamine + O2 + H2O | 100% activity | Microbacterium oxydans IH-35A | cyclohexanone + NH3 + H2O2 | - |
? | |
cyclooctanamine + O2 + H2O | 23% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
hexan-1-amine + O2 + H2O | 1% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
additional information | no activity with (R)-alpha-methylbenzylamine, 2-methylpiperidine and tetrahydroquinaldine | Microbacterium oxydans | ? | - |
? | |
additional information | when cyclohexylamine oxidase in combination with a borane-ammonia complex as reducing agent is applied to the deracemization of several substrates, excellent enantiomeric ratios (higher than 99:1) and good isolated yields (62-75%) of the corresponding (R)-amines are obtained | Microbacterium oxydans | ? | - |
? | |
additional information | no activity with (R)-alpha-methylbenzylamine, 2-methylpiperidine and tetrahydroquinaldine | Microbacterium oxydans IH-35A | ? | - |
? | |
additional information | when cyclohexylamine oxidase in combination with a borane-ammonia complex as reducing agent is applied to the deracemization of several substrates, excellent enantiomeric ratios (higher than 99:1) and good isolated yields (62-75%) of the corresponding (R)-amines are obtained | Microbacterium oxydans IH-35A | ? | - |
? | |
N-methylcyclohexanamine + O2 + H2O | 6% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? | |
trans-2-aminocyclohexanol + O2 + H2O | 16% activity compared to cyclohexylamine | Microbacterium oxydans | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CHAO | - |
Microbacterium oxydans |