BRENDA - Enzyme Database
show all sequences of 1.4.3.1

Characterization of the enzymatic and structural properties of human D-aspartate oxidase and comparison with those of the rat and mouse enzymes

Katane, M.; Kawata, T.; Nakayama, K.; Saitoh, Y.; Kaneko, Y.; Matsuda, S.; Saitoh, Y.; Miyamoto, T.; Sekine, M.; Homma, H.; Biol. Pharm. Bull. 38, 298-305 (2015)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) pLysS cells
Homo sapiens
expressed in Escherichia coli BL21(DE3) pLysS cells
Mus musculus
expressed in Escherichia coli BL21(DE3) pLysS cells
Rattus norvegicus
Inhibitors
Inhibitors
Commentary
Organism
Structure
Aminooxyacetate
66.4% residual activity at 1 mM
Homo sapiens
Aminooxyacetate
-
Mus musculus
Aminooxyacetate
-
Rattus norvegicus
Cu2+
90.7% residual activity at 1 mM
Homo sapiens
Fe2+
86.5% residual activity at 1 mM
Homo sapiens
L-Glu
89.3% residual activity at 1 mM
Homo sapiens
malonate
-
Homo sapiens
malonate
-
Mus musculus
malonate
-
Rattus norvegicus
meso-tartrate
-
Homo sapiens
meso-tartrate
-
Mus musculus
meso-tartrate
-
Rattus norvegicus
additional information
not inhibited by EDTA, ATP, ADP, AMP, cAMP, and L-Asp
Homo sapiens
Ni2+
93.3% residual activity at 1 mM
Homo sapiens
pyridoxal 5'-phosphate
93.5% residual activity at 0.2 mM
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.1
-
D-Asp
at pH 8.3 and 37C
Homo sapiens
2.26
-
D-Asp
at pH 8.3 and 37C
Rattus norvegicus
7.37
-
D-Asp
at pH 8.3 and 37C
Mus musculus
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
additional information
not influenced by Na+, K+, Mg2+, Ca2+, Co2+, Mn2+, and Zn2+
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-Asp + H2O + O2
Mus musculus
high activity
oxaloacetate + NH3 + H2O2
-
-
?
D-Asp + H2O + O2
Homo sapiens
high activity
oxaloacetate + NH3 + H2O2
-
-
?
D-Asp + H2O + O2
Rattus norvegicus
high activity
oxaloacetate + NH3 + H2O2
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q99489
-
-
Mus musculus
Q0E9Q7
-
-
Rattus norvegicus
D3ZDM7
-
-
Purification (Commentary)
Commentary
Organism
His GraviTrap column chromatography
Homo sapiens
His GraviTrap column chromatography
Mus musculus
His GraviTrap column chromatography
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
NRK-52E cell
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
0.12
-
with D-Pro as substrate, at pH 8.3 and 37C
Homo sapiens
0.14
-
with D-His as substrate, at pH 8.3 and 37C
Homo sapiens
0.16
-
with D-Asn as substrate, at pH 8.3 and 37C
Mus musculus
0.46
-
with D-Glu as substrate, at pH 8.3 and 37C
Mus musculus
0.47
-
with N-methyl-L-Asp as substrate, at pH 8.3 and 37C
Homo sapiens
2.93
-
with D-Asn as substrate, at pH 8.3 and 37C
Homo sapiens
3.17
-
with N-methyl-D-Glu as substrate, at pH 8.3 and 37C
Homo sapiens
7.82
-
with D-Glu as substrate, at pH 8.3 and 37C
Homo sapiens
12.2
-
with D-Asp as substrate, at pH 8.3 and 37C
Mus musculus
13.1
-
with N-methyl-D-Asp as substrate, at pH 8.3 and 37C
Mus musculus
87.5
-
with D-Asp as substrate, at pH 8.3 and 37C
Homo sapiens
91.2
-
with N-methyl-D-Asp as substrate, at pH 8.3 and 37C
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-Asn + H2O + O2
low activity
742035
Mus musculus
2-oxosuccinamic acid + NH3 + H2O2
-
-
-
?
D-Asn + H2O + O2
low activity
742035
Homo sapiens
2-oxosuccinamic acid + NH3 + H2O2
-
-
-
?
D-Asp + H2O + O2
high activity
742035
Mus musculus
oxaloacetate + NH3 + H2O2
-
-
-
?
D-Asp + H2O + O2
high activity
742035
Homo sapiens
oxaloacetate + NH3 + H2O2
-
-
-
?
D-Asp + H2O + O2
high activity
742035
Rattus norvegicus
oxaloacetate + NH3 + H2O2
-
-
-
?
D-Glu + H2O + O2
low activity
742035
Mus musculus
2-oxoglutarate + H2O2 + NH3
-
-
-
?
D-Glu + H2O + O2
low activity
742035
Homo sapiens
2-oxoglutarate + H2O2 + NH3
-
-
-
?
D-His + H2O + O2
low activity
742035
Mus musculus
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
-
-
?
D-His + H2O + O2
low activity
742035
Homo sapiens
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
-
-
?
D-Pro + H2O + O2
low activity
742035
Mus musculus
2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
D-Pro + H2O + O2
low activity
742035
Homo sapiens
2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
additional information
the enzyme exhibits low activities towards D-Glu and N-methyl-D-Glu, D-Asn, D-Pro and D-His. There is no activity detected towards D-Gln, D-Ser, D-Thr, D-Tyr, D-Ala, D-Val, D-Leu, D-Ile, D-Phe, D-Met, D-Trp, D-cysteine, D-Lys, D-Arg, L-Asp, L-Glu, N-methyl-L-Glu, L-Asn, L-Gln, L-Ser, L-Thr, L-Tyr, L-Ala, L-Val, L-Leu, L-Ile, L-Pro, L-Phe, L-Met, L-Trp, L-cysteine, L-Lys, L-Arg, L-His, or Gly
742035
Homo sapiens
?
-
-
-
-
additional information
the enzyme exhibits no activity towards D-Gln, D-Ser, D-Thr, D-Ala, D-Val, D-Leu, D-Phe, D-Met, D-Trp, D-cysteine, D-Lys, D-Arg, L-Asp, L-Glu, L-Asn, L-Gln, L-Ser, L-Thr, L-Ala, L-Val, L-Leu, L-Phe, L-Met, L-Trp, L-cysteine, L-Lys, L-Arg, or L-His
742035
Mus musculus
?
-
-
-
-
N-methyl-D-Asp + H2O + O2
high activity
742035
Mus musculus
oxaloacetate + methylamine + H2O2
-
-
-
?
N-methyl-D-Asp + H2O + O2
high activity
742035
Homo sapiens
oxaloacetate + methylamine + H2O2
-
-
-
?
N-methyl-D-Glu + H2O + O2
low activity
742035
Mus musculus
2-oxoglutarate + methylamine + H2O2
-
-
-
?
N-methyl-D-Glu + H2O + O2
low activity
742035
Homo sapiens
2-oxoglutarate + methylamine + H2O2
-
-
-
?
N-methyl-L-Asp + + H2O + O2
low activity
742035
Mus musculus
oxaloacetate + methylamine + H2O2
-
-
-
?
N-methyl-L-Asp + + H2O + O2
low activity
742035
Homo sapiens
oxaloacetate + methylamine + H2O2
-
-
-
?
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
45
-
-
Homo sapiens
Temperature Stability [C]
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
30
60
after 30 min of incubation, there is no loss of activity until the preincubation temperature reaches 45C, and 9% of the maximum activity is lost at 50C. The enzyme retains half of its maximum activity at 55C, while almost all of the activity is lost at 60C
Homo sapiens
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
9.83
-
D-Asp
at pH 8.3 and 37C
Mus musculus
31.1
-
D-Asp
at pH 8.3 and 37C
Rattus norvegicus
68.4
-
D-Asp
at pH 8.3 and 37C
Homo sapiens
pH Range
pH Minimum
pH Maximum
Commentary
Organism
6
12.5
the activity increases gradually as the pH is increased from 6.0 to 8.3, remains approximately constant at pH 8.3 to 12.5, and decreases rapidly when the pH is greater than 12.5. No enzymatic activity is detected at very low and high pH levels (5.0 and 13.0), respectively
Homo sapiens
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
7.5
12
after 30 min incubation time, the enzyme is stable at pH 8.3 to 11.0 and retains 80% and 60% of its maximum activity at pH 7.5 and pH 12.0, respectively
Homo sapiens
Cofactor
Cofactor
Commentary
Organism
Structure
FAD
-
Homo sapiens
FAD
-
Rattus norvegicus
FAD
-
Mus musculus
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.153
-
malonate
at pH 8.3 and 37C
Homo sapiens
0.472
-
meso-tartrate
at pH 8.3 and 37C
Rattus norvegicus
0.681
-
meso-tartrate
at pH 8.3 and 37C
Homo sapiens
1.22
-
malonate
at pH 8.3 and 37C
Mus musculus
1.416
-
Aminooxyacetate
at pH 8.3 and 37C
Rattus norvegicus
1.492
-
Aminooxyacetate
at pH 8.3 and 37C
Homo sapiens
1.562
-
malonate
at pH 8.3 and 37C
Rattus norvegicus
1.915
-
Aminooxyacetate
at pH 8.3 and 37C
Mus musculus
2.089
-
meso-tartrate
at pH 8.3 and 37C
Mus musculus
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) pLysS cells
Homo sapiens
expressed in Escherichia coli BL21(DE3) pLysS cells
Mus musculus
expressed in Escherichia coli BL21(DE3) pLysS cells
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
FAD
-
Homo sapiens
FAD
-
Rattus norvegicus
FAD
-
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Aminooxyacetate
66.4% residual activity at 1 mM
Homo sapiens
Aminooxyacetate
-
Mus musculus
Aminooxyacetate
-
Rattus norvegicus
Cu2+
90.7% residual activity at 1 mM
Homo sapiens
Fe2+
86.5% residual activity at 1 mM
Homo sapiens
L-Glu
89.3% residual activity at 1 mM
Homo sapiens
malonate
-
Homo sapiens
malonate
-
Mus musculus
malonate
-
Rattus norvegicus
meso-tartrate
-
Homo sapiens
meso-tartrate
-
Mus musculus
meso-tartrate
-
Rattus norvegicus
additional information
not inhibited by EDTA, ATP, ADP, AMP, cAMP, and L-Asp
Homo sapiens
Ni2+
93.3% residual activity at 1 mM
Homo sapiens
pyridoxal 5'-phosphate
93.5% residual activity at 0.2 mM
Homo sapiens
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.153
-
malonate
at pH 8.3 and 37C
Homo sapiens
0.472
-
meso-tartrate
at pH 8.3 and 37C
Rattus norvegicus
0.681
-
meso-tartrate
at pH 8.3 and 37C
Homo sapiens
1.22
-
malonate
at pH 8.3 and 37C
Mus musculus
1.416
-
Aminooxyacetate
at pH 8.3 and 37C
Rattus norvegicus
1.492
-
Aminooxyacetate
at pH 8.3 and 37C
Homo sapiens
1.562
-
malonate
at pH 8.3 and 37C
Rattus norvegicus
1.915
-
Aminooxyacetate
at pH 8.3 and 37C
Mus musculus
2.089
-
meso-tartrate
at pH 8.3 and 37C
Mus musculus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.1
-
D-Asp
at pH 8.3 and 37C
Homo sapiens
2.26
-
D-Asp
at pH 8.3 and 37C
Rattus norvegicus
7.37
-
D-Asp
at pH 8.3 and 37C
Mus musculus
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
additional information
not influenced by Na+, K+, Mg2+, Ca2+, Co2+, Mn2+, and Zn2+
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-Asp + H2O + O2
Mus musculus
high activity
oxaloacetate + NH3 + H2O2
-
-
?
D-Asp + H2O + O2
Homo sapiens
high activity
oxaloacetate + NH3 + H2O2
-
-
?
D-Asp + H2O + O2
Rattus norvegicus
high activity
oxaloacetate + NH3 + H2O2
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
His GraviTrap column chromatography
Homo sapiens
His GraviTrap column chromatography
Mus musculus
His GraviTrap column chromatography
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
NRK-52E cell
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
0.12
-
with D-Pro as substrate, at pH 8.3 and 37C
Homo sapiens
0.14
-
with D-His as substrate, at pH 8.3 and 37C
Homo sapiens
0.16
-
with D-Asn as substrate, at pH 8.3 and 37C
Mus musculus
0.46
-
with D-Glu as substrate, at pH 8.3 and 37C
Mus musculus
0.47
-
with N-methyl-L-Asp as substrate, at pH 8.3 and 37C
Homo sapiens
2.93
-
with D-Asn as substrate, at pH 8.3 and 37C
Homo sapiens
3.17
-
with N-methyl-D-Glu as substrate, at pH 8.3 and 37C
Homo sapiens
7.82
-
with D-Glu as substrate, at pH 8.3 and 37C
Homo sapiens
12.2
-
with D-Asp as substrate, at pH 8.3 and 37C
Mus musculus
13.1
-
with N-methyl-D-Asp as substrate, at pH 8.3 and 37C
Mus musculus
87.5
-
with D-Asp as substrate, at pH 8.3 and 37C
Homo sapiens
91.2
-
with N-methyl-D-Asp as substrate, at pH 8.3 and 37C
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-Asn + H2O + O2
low activity
742035
Mus musculus
2-oxosuccinamic acid + NH3 + H2O2
-
-
-
?
D-Asn + H2O + O2
low activity
742035
Homo sapiens
2-oxosuccinamic acid + NH3 + H2O2
-
-
-
?
D-Asp + H2O + O2
high activity
742035
Mus musculus
oxaloacetate + NH3 + H2O2
-
-
-
?
D-Asp + H2O + O2
high activity
742035
Homo sapiens
oxaloacetate + NH3 + H2O2
-
-
-
?
D-Asp + H2O + O2
high activity
742035
Rattus norvegicus
oxaloacetate + NH3 + H2O2
-
-
-
?
D-Glu + H2O + O2
low activity
742035
Mus musculus
2-oxoglutarate + H2O2 + NH3
-
-
-
?
D-Glu + H2O + O2
low activity
742035
Homo sapiens
2-oxoglutarate + H2O2 + NH3
-
-
-
?
D-His + H2O + O2
low activity
742035
Mus musculus
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
-
-
?
D-His + H2O + O2
low activity
742035
Homo sapiens
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
-
-
?
D-Pro + H2O + O2
low activity
742035
Mus musculus
2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
D-Pro + H2O + O2
low activity
742035
Homo sapiens
2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
additional information
the enzyme exhibits low activities towards D-Glu and N-methyl-D-Glu, D-Asn, D-Pro and D-His. There is no activity detected towards D-Gln, D-Ser, D-Thr, D-Tyr, D-Ala, D-Val, D-Leu, D-Ile, D-Phe, D-Met, D-Trp, D-cysteine, D-Lys, D-Arg, L-Asp, L-Glu, N-methyl-L-Glu, L-Asn, L-Gln, L-Ser, L-Thr, L-Tyr, L-Ala, L-Val, L-Leu, L-Ile, L-Pro, L-Phe, L-Met, L-Trp, L-cysteine, L-Lys, L-Arg, L-His, or Gly
742035
Homo sapiens
?
-
-
-
-
additional information
the enzyme exhibits no activity towards D-Gln, D-Ser, D-Thr, D-Ala, D-Val, D-Leu, D-Phe, D-Met, D-Trp, D-cysteine, D-Lys, D-Arg, L-Asp, L-Glu, L-Asn, L-Gln, L-Ser, L-Thr, L-Ala, L-Val, L-Leu, L-Phe, L-Met, L-Trp, L-cysteine, L-Lys, L-Arg, or L-His
742035
Mus musculus
?
-
-
-
-
N-methyl-D-Asp + H2O + O2
high activity
742035
Mus musculus
oxaloacetate + methylamine + H2O2
-
-
-
?
N-methyl-D-Asp + H2O + O2
high activity
742035
Homo sapiens
oxaloacetate + methylamine + H2O2
-
-
-
?
N-methyl-D-Glu + H2O + O2
low activity
742035
Mus musculus
2-oxoglutarate + methylamine + H2O2
-
-
-
?
N-methyl-D-Glu + H2O + O2
low activity
742035
Homo sapiens
2-oxoglutarate + methylamine + H2O2
-
-
-
?
N-methyl-L-Asp + + H2O + O2
low activity
742035
Mus musculus
oxaloacetate + methylamine + H2O2
-
-
-
?
N-methyl-L-Asp + + H2O + O2
low activity
742035
Homo sapiens
oxaloacetate + methylamine + H2O2
-
-
-
?
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
45
-
-
Homo sapiens
Temperature Stability [C] (protein specific)
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
30
60
after 30 min of incubation, there is no loss of activity until the preincubation temperature reaches 45C, and 9% of the maximum activity is lost at 50C. The enzyme retains half of its maximum activity at 55C, while almost all of the activity is lost at 60C
Homo sapiens
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
9.83
-
D-Asp
at pH 8.3 and 37C
Mus musculus
31.1
-
D-Asp
at pH 8.3 and 37C
Rattus norvegicus
68.4
-
D-Asp
at pH 8.3 and 37C
Homo sapiens
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
6
12.5
the activity increases gradually as the pH is increased from 6.0 to 8.3, remains approximately constant at pH 8.3 to 12.5, and decreases rapidly when the pH is greater than 12.5. No enzymatic activity is detected at very low and high pH levels (5.0 and 13.0), respectively
Homo sapiens
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
7.5
12
after 30 min incubation time, the enzyme is stable at pH 8.3 to 11.0 and retains 80% and 60% of its maximum activity at pH 7.5 and pH 12.0, respectively
Homo sapiens
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
1.354
-
D-Asp
at pH 8.3 and 37C
Mus musculus
14.104
-
D-Asp
at pH 8.3 and 37C
Rattus norvegicus
32.651
-
D-Asp
at pH 8.3 and 37C
Homo sapiens
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
1.354
-
D-Asp
at pH 8.3 and 37C
Mus musculus
14.104
-
D-Asp
at pH 8.3 and 37C
Rattus norvegicus
32.651
-
D-Asp
at pH 8.3 and 37C
Homo sapiens
Other publictions for EC 1.4.3.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
742426
Florio
Tracking the evolution of epi ...
Mus musculus
Epigenetics
12
41-54
2017
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1
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2
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6
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1
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6
-
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1
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743836
Sacchi
Olanzapine, but not clozapine ...
Homo sapiens, Mus musculus
Sci. Rep.
7
46288
2017
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4
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2
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6
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4
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2
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742805
Takahashi
Possible role of a histidine ...
Vanrija humicola
J. Biochem.
159
371-378
2016
-
-
1
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5
-
3
10
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1
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3
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9
1
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10
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1
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5
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3
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10
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9
1
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-
10
-
-
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10
10
743133
Punzo
Age-related changes in D-aspa ...
Mus musculus
J. Neurosci.
36
3064-3078
2016
-
-
-
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1
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5
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1
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1
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1
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1
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1
1
-
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-
742035
Katane
Characterization of the enzym ...
Homo sapiens, Mus musculus, Rattus norvegicus
Biol. Pharm. Bull.
38
298-305
2015
-
-
3
-
-
-
15
3
-
1
-
3
-
9
-
-
3
-
-
1
12
-
19
-
1
-
1
3
-
1
1
3
9
-
-
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-
3
3
-
-
-
-
15
9
3
-
1
-
3
-
-
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3
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1
12
-
19
-
1
-
1
3
-
1
1
-
-
-
-
-
3
3
743063
Katane
Identification of novel D-asp ...
Homo sapiens
J. Med. Chem.
58
7328-7340
2015
-
-
1
-
-
-
37
-
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1
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2
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1
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3
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33
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1
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33
37
3
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1
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1
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743140
Han
Changes in D-aspartic acid an ...
Mus musculus
J. Pharm. Biomed. Anal.
116
47-52
2015
-
-
-
-
-
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1
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4
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7
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1
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7
-
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1
-
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-
-
-
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-
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-
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-
743350
Cristino
D-aspartate oxidase influence ...
Mus musculus
Neurobiol. Aging
36
1890-1902
2015
-
-
-
-
-
-
-
-
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1
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1
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2
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1
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2
-
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1
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-
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1
1
-
-
-
741688
Takahashi
A highly stable d-amino acid ...
no activity in Rubrobacter xylanophilus
Appl. Environ. Microbiol.
80
7219-7229
2014
-
-
-
-
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4
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-
-
-
-
-
-
-
723870
Senda
Crystallization and preliminar ...
Sus scrofa
Acta Crystallogr. Sect. F
68
644-646
2012
-
-
1
1
-
-
-
-
-
-
1
1
-
3
-
-
1
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2
-
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1
1
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1
-
1
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1
1
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1
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2
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1
1
-
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-
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-
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-
-
-
-
724597
Kato
Enzymatic assay for D-aspartic ...
Vanrija humicola
Biosci. Biotechnol. Biochem.
76
2150-2152
2012
-
-
-
-
-
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2
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1
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3
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2
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2
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1
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1
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2
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2
-
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2
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-
-
-
-
725959
Saitoh
Spatiotemporal localization of ...
Caenorhabditis elegans, Caenorhabditis elegans N2
Mol. Cell. Biol.
32
1967-1983
2012
-
-
1
-
-
-
-
-
-
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6
-
21
-
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8
-
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6
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1
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3
3
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6
-
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14
-
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6
-
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-
-
-
-
-
-
-
-
1
3
-
-
-
711325
Katane
Thiolactomycin inhibits D-aspa ...
Homo sapiens, Mus musculus
Biochimie
92
1371-1378
2010
-
-
1
-
1
-
6
-
-
-
-
2
-
3
-
-
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-
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1
-
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4
-
1
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-
1
-
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2
4
-
3
-
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1
2
-
1
-
3
6
4
-
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-
-
2
-
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-
-
1
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
711718
Katane
Comparative characterization o ...
Caenorhabditis elegans
Chem. Biodivers.
7
1424-1434
2010
-
-
1
-
-
-
-
10
3
-
3
3
-
4
-
-
1
-
-
-
-
-
4
1
1
-
-
9
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
10
3
-
3
3
-
-
-
1
-
-
-
-
4
1
1
-
-
9
1
-
-
-
-
1
1
-
9
9
711719
Katane
D-aspartate oxidase: The sole ...
Bos taurus, Caenorhabditis elegans, Homo sapiens, Mus musculus, Ovis aries, Rattus norvegicus, Sus scrofa, Vanrija humicola
Chem. Biodivers.
7
1435-1449
2010
-
2
5
-
4
-
24
-
12
-
-
17
-
9
-
-
5
-
-
40
-
-
28
8
-
-
-
-
-
-
-
8
-
-
-
-
2
5
8
-
4
-
-
24
-
-
12
-
-
17
-
-
-
5
-
40
-
-
28
8
-
-
-
-
-
-
-
-
-
4
4
-
-
-
711721
Burrone
Effects of D-aspartate treatme ...
Pelophylax esculentus
Chem. Biodivers.
7
1459-1466
2010
-
-
-
-
-
-
-
-
1
-
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1
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3
-
-
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5
-
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1
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1
-
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-
1
-
-
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1
-
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1
-
-
-
-
-
5
-
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1
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
711722
Topo
Thyroid hormones and D-asparti ...
Mus musculus, Rattus norvegicus
Chem. Biodivers.
7
1467-1478
2010
-
-
-
-
-
-
-
2
-
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-
2
-
5
-
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-
4
-
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2
-
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-
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2
-
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-
2
-
-
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2
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2
-
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4
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
712616
di Giovanni
Distribution of free D-asparti ...
Pelophylax esculentus
J. Exp. Zool.
313 A
137-143
2010
-
-
-
-
-
-
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10
-
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3
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5
-
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5
-
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4
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1
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1
1
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-
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-
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-
-
-
-
-
-
-
-
10
-
-
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3
-
-
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5
-
-
4
-
1
-
-
-
1
1
-
-
1
1
1
1
-
-
712818
Yamamoto
D-aspartate oxidase localisati ...
Sus scrofa
J. Neuroendocrinol.
22
1165-1172
2010
-
-
-
-
-
-
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-
1
-
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1
-
4
-
-
-
-
-
7
-
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1
-
1
-
-
-
1
-
-
1
-
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-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
7
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
712787
Takahashi
-
An active-site mutation enhanc ...
Vanrija humicola
J. Mol. Catal. B
61
235-240
2009
-
-
1
-
5
-
-
11
-
-
-
1
-
1
-
-
1
-
-
-
15
-
5
1
1
-
-
5
1
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
11
-
-
-
1
-
-
-
1
-
-
15
-
5
1
1
-
-
5
1
-
-
-
-
-
-
-
7
7
684387
Katane
Hyperactive mutants of mouse D ...
Mus musculus
Amino Acids
35
75-82
2008
-
-
1
-
3
-
-
12
-
-
-
-
-
3
-
-
1
-
-
1
12
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
12
-
-
-
-
-
-
-
1
-
1
12
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686597
Huang
D-Aspartate and D-aspartate ox ...
Mus musculus
Exp. Eye Res.
86
704-709
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673583
Katane
Caenorhabditis elegans has two ...
Caenorhabditis elegans
FEBS J.
274
137-149
2007
-
-
1
-
-
-
-
10
-
-
4
-
-
3
-
-
1
-
-
-
-
-
17
-
-
-
-
10
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
10
-
-
4
-
-
-
-
1
-
-
-
-
17
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
684383
Katane
Molecular cloning of a cDNA en ...
Mus musculus
Amino Acids
32
69-78
2007
-
-
1
-
7
-
3
-
-
-
1
-
-
3
-
-
-
-
-
2
-
-
7
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
7
-
-
3
-
-
-
-
1
-
-
-
-
-
-
2
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687440
Yamamoto
Functional and structural char ...
Sus scrofa
J. Biochem.
141
363-376
2007
2
-
1
-
-
-
2
3
-
-
4
-
-
3
-
-
1
-
-
2
2
-
3
1
-
-
-
3
1
-
1
1
-
-
-
2
-
1
1
-
-
-
-
2
-
3
-
-
4
-
-
-
-
1
-
2
2
-
3
1
-
-
-
3
1
-
1
-
-
-
-
-
-
-
677271
Takahashi
Physiological role of D-aspart ...
Vanrija humicola
Yeast
22
1203-1212
2005
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
655928
Takahashi
Cloning and expression in Esch ...
Vanrija humicola
J. Biochem.
135
533-540
2004
-
-
1
-
-
-
2
3
-
-
3
-
-
6
-
-
1
-
-
-
1
-
3
1
1
-
2
3
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
3
-
-
3
-
-
-
-
1
-
-
1
-
3
1
1
-
2
3
1
-
-
-
-
-
-
-
-
-
657350
Sarower
-
Distribution and substrate spe ...
Meretrix lusoria, Mizuhopecten yessoensis, Mytilus galloprovincialis, Octopus vulgaris, Penaeus japonicus, Procambarus clarkii, Todarodes pacificus, Turbo cornutus
Science Asia
30
335-340
2004
-
-
-
-
-
-
-
-
-
-
-
8
-
8
-
-
-
-
-
14
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
14
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656415
Sarower
Distribution and characteristi ...
Chaunax fimbriatus, Cololabis saira, Cyprinus carpio, Dentex tumifrons, Lateolabrax japonicus, Oncorhynchus keta, Oncorhynchus masou, Oncorhynchus mykiss, Pagrus major, Paralichthys olivaceus, Plecoglossus altivelis, Pseudopleuronectes yokohamae, Sardinops melanostictus, Scomber japonicus, Thamnaconus tessellatus, Trachurus japonicus, Verasper variegatus
J. Exp. Zool. A
295
151-159
2003
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17
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23
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38
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17
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38
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25
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1
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391705
Sacchi
Engineering the substrate spec ...
Bos taurus
J. Biol. Chem.
277
27510-27516
2002
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4
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391706
Zaar
Cellular and subcellular distr ...
Bos taurus, Homo sapiens, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
J. Comp. Neurol.
450
272-282
2002
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166
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16
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391707
Negri
Purification of beef kidney D- ...
Bos taurus
Biochim. Biophys. Acta
1431
212-222
1999
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1
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1
10
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1
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3
1
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1
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1
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10
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1
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11
1
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391708
Tedeschi
D-Aspartate oxidase is present ...
Bos taurus, Xenopus laevis
Comp. Biochem. Physiol. B
124
489-494
1999
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2
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1
2
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7
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2
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6
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391709
Amery
C-terminal tripeptide Ser-Asn- ...
Homo sapiens
Biochem. J.
336
367-371
1998
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1
1
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391710
Kera
-
D-Aspartate oxidase and free a ...
Carassius auratus langsdorfii, Cyprinus carpio, Oncorhynchus mykiss, Pagrus major, Seriola quinqueradiata
Comp. Biochem. Physiol. B
119
95-100
1998
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7
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11
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24
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9
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11
11
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24
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391711
Simonic
cDNA cloning and expression of ...
Bos taurus
Biochem. J.
322
729-735
1997
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1
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391712
Setoyama
Structural and functional char ...
Homo sapiens
J. Biochem.
121
798-803
1997
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1
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2
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1
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4
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391713
Yamada
Purification and properties of ...
Vanrija humicola, Vanrija humicola UJ1
Biochim. Biophys. Acta
1294
153-158
1996
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3
3
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2
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6
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1
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3
3
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1
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8
1
1
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1
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391714
Tedeschi
Properties of the flavoenzyme ...
Octopus vulgaris
Biochim. Biophys. Acta
1207
217-222
1994
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6
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1
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7
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1
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391715
Wakayama
-
Isolation, enzyme production a ...
Fusarium sacchari
J. Ferment. Bioeng.
78
377-379
1994
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4
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391716
D'Aniello
Biological role of D-amino aci ...
Mus musculus, Octopus vulgaris, Rattus norvegicus
J. Biol. Chem.
268
26941-26949
1993
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6
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391717
D'Aniello
Further study on the specifici ...
Bos taurus, Octopus vulgaris
Comp. Biochem. Physiol. B
105
731-734
1993
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14
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4
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2
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13
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14
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13
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391718
Tedeschi
Chemical modification of funct ...
Bos taurus
Eur. J. Biochem.
205
127-132
1992
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391719
Negri
-
Structural studies of beef kid ...
Bos taurus
Flavins and Flavoproteins (Proc. Int. Symp. , 10th, Meeting Date 1990, Curti, B. , Ronchi S. , Zanetti, G. , eds. ) de Gruyter, Berlin, New York
179-187
1990
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2
1
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1
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5
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1
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5
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1
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391720
Tedeschi
-
Modification of substrate spec ...
Bos taurus
Flavins and Flavoproteins (Proc. Int. Symp. , 10th, Meeting Date 1990, Curti, B. , Ronchi S. , Zanetti, G. , eds. ) de Gruyter, Berlin, New York
189-192
1990
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1
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6
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6
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391721
Negri
The kinetic mechanism of beef ...
Bos taurus
J. Biol. Chem.
263
13557-13563
1988
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2
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1
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1
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2
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391722
Negri
D-Aspartate oxidase from beef ...
Bos taurus
J. Biol. Chem.
262
10026-10034
1987
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1
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391723
Burns
Thiazolidine-2-carboxylate der ...
Bos taurus
Biochem. Biophys. Res. Commun.
125
1039-1045
1984
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4
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391724
Nasu
The mammalian enzyme which rep ...
Bos taurus
Biochim. Biophys. Acta
704
240-252
1982
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1
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1
-
2
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391725
Rinaldi
Oxidation of meso-diaminosucci ...
Bos taurus
Eur. J. Biochem.
117
635-638
1981
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2
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2
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2
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3
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391726
Jaroszewicz
D-Asparatate oxidase in the th ...
Sus scrofa
Enzyme
20
80-89
1975
-
-
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1
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1
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1
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3
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1
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391727
Dixon
D-aspartate oxidase of kidney ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
146
54-76
1967
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15
4
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1
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1
1
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15
2
4
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1
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3
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2
1
1
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391728
Still
-
On the prosthetic group of the ...
Oryctolagus cuniculus, Ovis aries, Sus scrofa
J. Biol. Chem.
182
585-589
1950
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