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Literature summary for 1.4.3.1 extracted from
- Thyroid hormones and D-aspartic acid, D-aspartate oxidase, D-aspartate racemase, H2O2, and ROS in rats and mice (2010), Chem. Biodivers., 7, 1467-1478.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 5.5 | - |
D-Aspartate | pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus |  |
| 7.5 | - |
D-Aspartate | pH not specified in the publication, temperature not specified in the publication | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-aspartate + H2O + O2 | Mus musculus | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
| D-aspartate + H2O + O2 | Rattus norvegicus | - |
oxaloacetate + NH3 + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| thyroid gland | with about 80 units/mg thyroid enzyme activity | Mus musculus | - |
| thyroid gland | with about 80 units/mg thyroid enzyme activity | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-aspartate + H2O + O2 | - |
Mus musculus | oxaloacetate + NH3 + H2O2 | - |
? | |
| D-aspartate + H2O + O2 | - |
Rattus norvegicus | oxaloacetate + NH3 + H2O2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| D-AspO | - |
Mus musculus |
| D-AspO | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Mus musculus | |
| FAD | - |
Rattus norvegicus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | H2O2 is essential for the iodination of the tyrosyl residues to produce mono- and diiodotyrosine that are the precursors for the synthesis of thyroid hormones T3 and T4. interaction of endogenous D-Asp, D-AspO, and D-aspartate racemase in thyroid gland constitutes an additional biochemical pathway for the production of H2O2 and consequently for the synthesis of thyroid hormones, overview | Mus musculus |
| metabolism | H2O2 is essential for the iodination of the tyrosyl residues to produce mono- and diiodotyrosine that are the precursors for the synthesis of thyroid hormones T3 and T4. interaction of endogenous D-Asp, D-AspO, and D-aspartate racemase in thyroid gland constitutes an additional biochemical pathway for the production of H2O2 and consequently for the synthesis of thyroid hormones, overview | Rattus norvegicus |
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