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Literature summary for 1.4.1.9 extracted from

  • Ohshima, T.; Soda, K.
    Modification of leucine dehydrogenase by pyridoxal 5'-phosphate (1984), Agric. Biol. Chem., 48, 349-354.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
pyridoxal 5'-phosphate fully protected from inactivation only by NADH Lysinibacillus sphaericus

Organism

Organism UniProt Comment Textmining
Lysinibacillus sphaericus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Leu + H2O + NAD+
-
Lysinibacillus sphaericus 4-methyl-2-oxopentanoate + NH3 + NADH
-
r
L-Val + H2O + NAD+
-
Lysinibacillus sphaericus 3-methyl-2-oxobutanoate + NH3 + NADH
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9 9.5 reductive amination of 4-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate, phosphopyridoxylated enzyme Lysinibacillus sphaericus
10.5 10.8 oxidative deamination of L-Leu and L-Val, phosphopyridoxylated enzyme Lysinibacillus sphaericus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Lysinibacillus sphaericus
NADH
-
Lysinibacillus sphaericus