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Literature summary for 1.4.1.4 extracted from

  • Harper, C.J.; Hayward, D.; Kidd, M.; Wiid, I.; van Helden, P.
    Glutamate dehydrogenase and glutamine synthetase are regulated in response to nitrogen availability in Myocbacterium smegmatis (2010), BMC Microbiol., 10, 138.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene msmeg_5442, semi-quantitative real-time PCR expression analysis Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate + H2O + NADP+ Mycolicibacterium smegmatis reaction cycle, specificities of forward and reverse reactions, overview 2-oxoglutarate + NH3 + NADPH + H+
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r

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis A0R3E3 gene msmeg_5442
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate + H2O + NADP+ reaction cycle, specificities of forward and reverse reactions, overview Mycolicibacterium smegmatis 2-oxoglutarate + NH3 + NADPH + H+
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r
L-glutamate + H2O + NADP+ reaction cycle, overview Mycolicibacterium smegmatis 2-oxoglutarate + NH3 + NADPH + H+
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r

Synonyms

Synonyms Comment Organism
GDH1
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Mycolicibacterium smegmatis
NADP+ - dependant-glutamate dehydrogenase
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Mycolicibacterium smegmatis
NADP+-Gdh
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Mycolicibacterium smegmatis

Cofactor

Cofactor Comment Organism Structure
NADP+ specific for Mycolicibacterium smegmatis
NADPH specific for Mycolicibacterium smegmatis

Expression

Organism Comment Expression
Mycolicibacterium smegmatis enzyme expression is upregulated under N2-starvation, overview up

General Information

General Information Comment Organism
metabolism NADP+-GDH is involved in nitrogen assimilation due to a constitutive aminating activity, specific activity of the aminating NADP+-GDH reaction is independent of nitrogen availability, it does not change significantly in response to prolonged exposure to nitrogen limitation, in contrast to the deaminating activity, which is 2fold increased exposed to ammonium starvation conditions. The deaminating reaction changes in response to varying ammonium concentrations and is regulated in response to nitrogen availability. NADP+-GDH is not regulated on the transcriptional level. The enzyme is invovled in the additional nitrogen assimilatory pathway via glutamate dehydrogenase, GDH, regulation of NADP+-GDH specific activity, overview Mycolicibacterium smegmatis