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Literature summary for 1.4.1.4 extracted from
- Disruption of the NADPH-dependent glutamate dehydrogenase affects the morphology of two industrial strains of Penicillium chrysogenum (2009), J. Biotechnol., 139, 280-282.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Penicillium chrysogenum | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glutamate dehydrogenase | - |
Penicillium chrysogenum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Penicillium chrysogenum |  |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | two industrial strains of Penicillium chrysogenum a penicillin (PC-pen)- and a cephalosporin producing (PC-ceph) are used in which the NADPH-dependent GDH is deleted by replacing 0.8 kb of the C-terminus of the gdhA gene with the hygromyin B resistance marker, resulting in PC-pen-DELTAgdhA and PC-ceph-DELTAgdhA. The two strains are isogenic except for the insertion of the Streptomyces clavuligerus expandase gene into the genome of PC-ceph. It is shown that this genetic modification results in a radical change in morphology | Penicillium chrysogenum |
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