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Literature summary for extracted from

  • Carrigan, J.B.; Engel, P.C.
    The structural basis of proteolytic activation of bovine glutamate dehydrogenase (2008), Protein Sci., 17, 1346-1353.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
ADP ADP activation is almost abolished after treatment with TLCK-treated chymotrypsin Bos taurus
chymotrypsin 0.2 mg/ml chymotrypsin cleaves glutamate dehydrogenase in such a fashion as to cause a rise in activity with NADP+ and NAD+ as coenzyme, over threefold activation in the NADP+ assay with TLCK-treated chymotrypsin, the distinguishing aspect with untreated chymotrypsin is that the activation is followed by a decrease in activity Bos taurus
additional information not inhibited by trypsin Bos taurus


Inhibitors Comment Organism Structure
GTP GTP inhibition is attenuated to some extent by the proteolysis with TLCK-treated chymotrypsin Bos taurus


Organism UniProt Comment Textmining
Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate + H2O + NAD(P)+
Bos taurus 2-oxoglutarate + NH3 + NAD(P)H + H+


Synonyms Comment Organism
Bos taurus


Cofactor Comment Organism Structure
Bos taurus
Bos taurus