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Literature summary for extracted from

  • Hamelin, M.; Mary, J.; Vostry, M.; Friguet, B.; Bakala, H.
    Glycation damage targets glutamate dehydrogenase in the rat liver mitochondrial matrix during aging (2007), FEBS J., 274, 5949-5961.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ADP 120.88% activity in the presence of 0.25 mM ATP Rattus norvegicus
leucine with 10 mM the activity increases by 1.55fold after 240 min and by 1.24fold when the enzyme is preincubated with methylglyoxal Rattus norvegicus


Inhibitors Comment Organism Structure
Glyoxal 67% inhibition at 1 mM Rattus norvegicus
GTP 8.23% activity in the presence of 0.01 mM ATP Rattus norvegicus
methylglyoxal with 1 mM methylglyoxal, GDH activity significantly decreases at 30 min of incubation, and markedly drops by 37% within 5 h compared to control Rattus norvegicus


Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix
Rattus norvegicus 5759

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
gel filtration Rattus norvegicus


Organism UniProt Comment Textmining
Rattus norvegicus P10860 precursor

Source Tissue

Source Tissue Comment Organism Textmining
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate + H2O + NAD+
Rattus norvegicus 2-oxoglutarate + NH3 + NADH + H+
L-glutamate + H2O + NADP+
Rattus norvegicus 2-oxoglutarate + NH3 + NADPH + H+


Synonyms Comment Organism
Rattus norvegicus
glutamate dehydrogenase 1
Rattus norvegicus


Cofactor Comment Organism Structure
NAD+ utilizes NAD+ for nitrogen liberation Rattus norvegicus
NADP+ utilizes NADP+ for nitrogen incorporation Rattus norvegicus

pI Value

Organism Comment pI Value Maximum pI Value
Rattus norvegicus isoelectric focusing