Literature summary for 1.4.1.27 extracted from

Yadav, U.; Sundd, M.
Backbone chemical shift assignments of the glycine cleavage complex H protein of Escherichia coli (2018), Biomol. NMR Assign., 12, 163-165 .

Search for more literature for 1.4.1.27

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
glycine cleavage complex	-	Escherichia coli

Expression

Organism	Comment	Expression
Escherichia coli	the activity of the glycine cleavage complex is repressed by purines	down
Escherichia coli	the activity of the glycine cleavage complex is induced in the presence of exogenous glycine	up

General Information

General Information	Comment	Organism
metabolism	the enzyme is one of the four components that form the glycine cleavage complex (GCS), essential for the synthesis of C1 (one-carbon units) for cell metabolism, by the oxidative cleavage of glycine. The glycine cleavage complex (GCS), in cooperation with GCA (serine hydroxymethyltransferase) regulates the endogenous levels of glycine and C1 units in the cell. This system comprises four loosely associated proteins, namely GcvP (a pyridoxal phosphate-containing protein), GcvH (a protein that carries aminomethyl intermediate), GcvT (protein required for tetrahydrofolate-dependent reaction) and GcvL (a lipoamide dehydrogenase). GcvP decarboxylates glycine and relocates the remaining methylamine moiety to the lipoyl group of GcvH	Escherichia coli

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Release 2023.1 (January 2023)