Literature summary for 1.4.1.27 extracted from

Yang, D.; Wang, Z.; Ma, J.; Fu, Q.; Wu, L.; Wang, H.; Wang, S.; Yan, Y.; Sun, J.
Glycine cleavage system and cAMP receptor protein co-regulate CRISPR/cas3 expression to resist bacteriophage (2020), Viruses, 12, 90 .

Search for more literature for 1.4.1.27

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P27248 and P0A6T9 and P33195	P27248 i.e. aminomethyltransferase component T-protein, cf. EC 2.1.2.10, P0A6T9 i.e. component H-protein, P33195 i.e. glycine dehydrogenase component P-protein, cf. EC 1.4.4.2	-

Synonyms

Synonyms	Comment	Organism
GcvH	H-protein	Escherichia coli
GcvP	glycine dehydrogenase	Escherichia coli
GCVT	aminomethyltransferase	Escherichia coli

General Information

General Information	Comment	Organism
physiological function	glycine cleavage system and cAMP receptor protein coregulate Cas3 of the CRISPR/Cas system and contribute to the defence against invasive genetic elements. Silencing of the glycine cleavage system encoded by the gcvTHP operon reduces Cas3 expression. Addition of N5,N10-methylene tetrahydrofolate activates Cas3 expression. A cAMP receptor protein encoded by Crp activates Cas3 expression via binding to the Cas3 promoter in response to cAMP concentration. The glycine cleavage system regulates Cas3 through association with cAMP receptor protein	Escherichia coli

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Release 2023.1 (January 2023)