Literature summary for 1.4.1.27 extracted from

Brown, M.J.; Russo, B.C.; ODee, D.M.; Schmitt, D.M.; Nau, G.J.
The contribution of the glycine cleavage system to the pathogenesis of Francisella tularensis (2014), Microbes Infect., 16, 300-309 .

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Organism

Organism	UniProt	Comment	Textmining
Francisella tularensis subsp. tularensis	Q5NHP0	Q5NHP0 i.e. aminomethyltransferase component T-protein, cf. EC 2.1.210	-

Synonyms

Synonyms	Comment	Organism
GCVT	-	Francisella tularensis subsp. tularensis

General Information

General Information	Comment	Organism
physiological function	deletion of the gcvT homolog, i.e. T-protein, in attenuated and virulent Francisella tularensis strains. Deletion mutants are auxotrophic for serine but behave similar to wild-type strains with respect to host cell invasion, intracellular replication, and stimulation of TNFalpha. The glycine cleavage system is required for the pathogenesis of virulent Francisella tularensis in a murine model. Deletion of the gcvT gene delays mortality and lowers bacterial burden, particularly in the liver and bloodstream	Francisella tularensis subsp. tularensis

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Release 2023.1 (January 2023)