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Literature summary for 1.4.1.27 extracted from
- Glycine metabolism by rat liver mitochondria. Reconstruction of the reversible glycine cleavage system with partially purified protein components (1974), Arch. Biochem. Biophys., 164, 624-633 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH | Rattus norvegicus | - |
glycine + tetrahydrofolate + NAD+ | - |
r |  |
| glycine + tetrahydrofolate + NAD+ | Rattus norvegicus | - |
5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| purification of P-protein, and for T-protein. The procedure leads to the isolation of a nearly homogeneous form of T-protein but P-protein still is heterogeneous | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH | - |
Rattus norvegicus | glycine + tetrahydrofolate + NAD+ | - |
r | |
| glycine + tetrahydrofolate + NAD+ | - |
Rattus norvegicus | 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| multimer | x * 33,000, component T-protein | Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the reversible glycine cleavage system is composed of four protein components named as P-, H-, L-, and T-protein, respectively. P-protein catalyzes the decarboxylation of glycine or its reverse reaction in the presence of H-protein, and T-protein participates in the formation of one carbon unit and ammonia or the reverse reaction | Rattus norvegicus |
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Release 2023.1 (January 2023)
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