Literature summary for 1.4.1.2 extracted from

Joshi, C.V.; Ghormade, V.; Kunde, P.; Kulkarni, P.; Mamgain, H.; Bhat, S.; Paknikar, K.M.; Deshpande, M.V.
Flocculation of dimorphic yeast Benjaminiella poitrasii is altered by modulation of NAD-glutamate dehydrogenase (2009), Biores. Technol., 101, 1393-1395.

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Application

Application	Comment	Organism
biotechnology	a strategy to control flocculation is investigated using dimorphic yeast, Benjaminiella poitrasii as a model. Parent form of this yeast (Y) exhibit faster flocculation (11.1 min) than the monomorphic yeast form mutant Y-5 (12.6 min). Flocculation of both Y and Y-5 can be altered by supplementing either substrates or inhibitor of NAD-glutamate dehydrogenase (NAD-GDH) in the growth media. The rate of flocculation is promoted by alpha-ketoglutarate or isophthalic acid and decelerated by glutamate with a statistically significant inverse correlation to corresponding NAD-GDH levels. This opens up new possibilities of using NAD-GDH modulating agents to control flocculation in fermentations for easier downstream processing	Benjaminiella poitrasii
biotechnology	the rate of flocculation is promoted by a-ketoglutarate or isophthalic acid and decelerated by glutamate with a statistically significant inverse correlation to corresponding NAD-GDH levels. These interesting findings open up new possibilities of using NAD-GDH modulating agents to control flocculation in fermentations for easier downstream processing	Benjaminiella poitrasii

Inhibitors

Inhibitors	Comment	Organism	Structure
isophthalic acid	-	Benjaminiella poitrasii

Organism

Organism	UniProt	Comment	Textmining
Benjaminiella poitrasii	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-oxoglutarate + NADH + NH3	-	Benjaminiella poitrasii	L-glutamate + NAD+ + H2O	-	?
L-glutamate + H2O + NADP+	-	Benjaminiella poitrasii	2-oxoglutarate + NH3 + NADPH	-	?

Synonyms

Synonyms	Comment	Organism
NAD-GDH	-	Benjaminiella poitrasii
NAD-glutamate dehydrogenase	-	Benjaminiella poitrasii

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Benjaminiella poitrasii

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Release 2023.1 (January 2023)