Literature summary for 1.4.1.16 extracted from

Yeh, P.; Sicard, A.M.; Sinskey, A.J.
General organization of the genes specifically involved in the diaminopimelate-lysine biosynthetic pathway of Corynebacterium glutamicum (1988), Mol. Gen. Genet., 212, 105-111.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Corynebacterium glutamicum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-2-amino-6-oxoheptanedioate + NH3 + NADPH	Corynebacterium glutamicum	-	meso-2,6-diaminoheptanedioate + H2O + NADP+	-	r
L-2-amino-6-oxoheptanedioate + NH3 + NADPH	Corynebacterium glutamicum AS019	-	meso-2,6-diaminoheptanedioate + H2O + NADP+	-	r

Organism

Organism	UniProt	Comment	Textmining
Corynebacterium glutamicum	-	-	-
Corynebacterium glutamicum AS019	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.13	-	strain AS019 transformed with plasmid harboring cloned gene	Corynebacterium glutamicum

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H	-	Corynebacterium glutamicum	meso-2,6-diaminoheptanedioate + H2O + NAD(P)+	-	r
L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H	-	Corynebacterium glutamicum AS019	meso-2,6-diaminoheptanedioate + H2O + NAD(P)+	-	r
L-2-amino-6-oxoheptanedioate + NH3 + NADPH	-	Corynebacterium glutamicum	meso-2,6-diaminoheptanedioate + H2O + NADP+	-	r
L-2-amino-6-oxoheptanedioate + NH3 + NADPH	-	Corynebacterium glutamicum AS019	meso-2,6-diaminoheptanedioate + H2O + NADP+	-	r

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Corynebacterium glutamicum

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Release 2023.1 (January 2023)