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Literature summary for 1.4.1.14 extracted from

  • Khanna, S.; Nicholas, D.J.D.
    Some properties of glutamine synthetase and glutamate synthase from Chlorobium vibrioforme f. thiosulfatophilum (1983), Arch. Microbiol., 134, 98-103.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
diphosphate 5 mM, stimulates activity with 36% enhancement Prosthecochloris vibrioformis f. thiosulfatophilum
succinate 50 mM, stimulates activity by 57% Prosthecochloris vibrioformis f. thiosulfatophilum

Inhibitors

Inhibitors Comment Organism Structure
ADP 20 mM, about 75% inhibition Prosthecochloris vibrioformis f. thiosulfatophilum
alanine slight inhibition Prosthecochloris vibrioformis f. thiosulfatophilum
AMP 20 mM, about 75% inhibition Prosthecochloris vibrioformis f. thiosulfatophilum
arginine 20 mM, complete inhibition Prosthecochloris vibrioformis f. thiosulfatophilum
Atebrin
-
Prosthecochloris vibrioformis f. thiosulfatophilum
ATP 5 mM, 75% inhibition Prosthecochloris vibrioformis f. thiosulfatophilum
glycine 48% inhibition at 10 mM, complete inhibition at 20 mM Prosthecochloris vibrioformis f. thiosulfatophilum
leucine 10 mM, 52% inhibition Prosthecochloris vibrioformis f. thiosulfatophilum
malate 20 mM, 30% inhibition Prosthecochloris vibrioformis f. thiosulfatophilum
methionine 10 mM, 72% inhibition Prosthecochloris vibrioformis f. thiosulfatophilum
additional information cumulative inhibition by combinations of amino acids and nucleotides, cumulative feedback inhibition Prosthecochloris vibrioformis f. thiosulfatophilum
NAD+ 1 mM, 27% inhibition Prosthecochloris vibrioformis f. thiosulfatophilum
NADP+ 1 mM, 48% inhibition Prosthecochloris vibrioformis f. thiosulfatophilum
phenylalanine 20 mM, complete inhibition Prosthecochloris vibrioformis f. thiosulfatophilum
proline
-
Prosthecochloris vibrioformis f. thiosulfatophilum
pyruvate 20 mM, 20% inhibition Prosthecochloris vibrioformis f. thiosulfatophilum
serine 10 mM, 73% inhibition Prosthecochloris vibrioformis f. thiosulfatophilum
tryptophan 29% inhibition at 10 mM, complete inhibition at 20 mM Prosthecochloris vibrioformis f. thiosulfatophilum
valine
-
Prosthecochloris vibrioformis f. thiosulfatophilum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.013
-
NADH
-
Prosthecochloris vibrioformis f. thiosulfatophilum
0.27
-
2-oxoglutarate
-
Prosthecochloris vibrioformis f. thiosulfatophilum
0.769
-
L-glutamine
-
Prosthecochloris vibrioformis f. thiosulfatophilum

Localization

Localization Comment Organism GeneOntology No. Textmining
chromatophore
-
Prosthecochloris vibrioformis f. thiosulfatophilum
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamine + 2-oxoglutarate + NADH Prosthecochloris vibrioformis f. thiosulfatophilum glutamine synthetase/glutamate synthase pathway for ammonia assimilation is fafavoured by growth at low concentrations of ammonia glutamate + NAD+
-
ir
L-glutamine + 2-oxoglutarate + NADH Prosthecochloris vibrioformis f. thiosulfatophilum key enzyme for glutamate production glutamate + NAD+
-
ir
L-glutamine + 2-oxoglutarate + NADH Prosthecochloris vibrioformis f. thiosulfatophilum NCIB 8346 glutamine synthetase/glutamate synthase pathway for ammonia assimilation is fafavoured by growth at low concentrations of ammonia glutamate + NAD+
-
ir
L-glutamine + 2-oxoglutarate + NADH Prosthecochloris vibrioformis f. thiosulfatophilum NCIB 8346 key enzyme for glutamate production glutamate + NAD+
-
ir

Organism

Organism UniProt Comment Textmining
Prosthecochloris vibrioformis f. thiosulfatophilum
-
-
-
Prosthecochloris vibrioformis f. thiosulfatophilum NCIB 8346
-
-
-

Purification (Commentary)

Purification (Comment) Organism
222fold purification Prosthecochloris vibrioformis f. thiosulfatophilum

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.7
-
-
Prosthecochloris vibrioformis f. thiosulfatophilum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamine + 2-oxoglutarate + NADH highly specific for its substrates Prosthecochloris vibrioformis f. thiosulfatophilum L-glutamate + NAD+
-
ir
L-glutamine + 2-oxoglutarate + NADH specific for NADH Prosthecochloris vibrioformis f. thiosulfatophilum L-glutamate + NAD+
-
ir
L-glutamine + 2-oxoglutarate + NADH highly specific for its substrates Prosthecochloris vibrioformis f. thiosulfatophilum NCIB 8346 L-glutamate + NAD+
-
ir
L-glutamine + 2-oxoglutarate + NADH specific for NADH Prosthecochloris vibrioformis f. thiosulfatophilum NCIB 8346 L-glutamate + NAD+
-
ir
L-glutamine + 2-oxoglutarate + NADH glutamine synthetase/glutamate synthase pathway for ammonia assimilation is fafavoured by growth at low concentrations of ammonia Prosthecochloris vibrioformis f. thiosulfatophilum glutamate + NAD+
-
ir
L-glutamine + 2-oxoglutarate + NADH key enzyme for glutamate production Prosthecochloris vibrioformis f. thiosulfatophilum glutamate + NAD+
-
ir
L-glutamine + 2-oxoglutarate + NADH glutamine synthetase/glutamate synthase pathway for ammonia assimilation is fafavoured by growth at low concentrations of ammonia Prosthecochloris vibrioformis f. thiosulfatophilum NCIB 8346 glutamate + NAD+
-
ir
L-glutamine + 2-oxoglutarate + NADH key enzyme for glutamate production Prosthecochloris vibrioformis f. thiosulfatophilum NCIB 8346 glutamate + NAD+
-
ir

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Prosthecochloris vibrioformis f. thiosulfatophilum

Cofactor

Cofactor Comment Organism Structure
flavin flavin component Prosthecochloris vibrioformis f. thiosulfatophilum
NADH specific for NADH as reductant Prosthecochloris vibrioformis f. thiosulfatophilum