Literature summary for 1.4.1.1 extracted from

Giffin, M.M.; Shi, L.; Gennaro, M.L.; Sohaskey, C.D.
Role of alanine dehydrogenase of Mycobacterium tuberculosis during recovery from hypoxic nonreplicating persistence (2016), PLoS ONE, 11, e0155522 .

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Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WQB1	-	-
Mycobacterium tuberculosis H37Rv	P9WQB1	-	-

Expression

Organism	Comment	Expression
Mycobacterium tuberculosis	both mRNA levels and enzymatic activity increase during entry into nonreplicating persistence. Expression is also induced in vitro by persistence-inducing stresses such as nitric oxide, and the gene is expressed at high levels in vivo during the initial lung infection in mice	up

General Information

General Information	Comment	Organism
physiological function	both mRNA levels and enzymatic activities of isocitrate lyase, and alanine dehydrogenase increases during entry into nonreplicating persistence. Expression of alanine dehydrogenase is also induced in vitro by persistence-inducing stresses such as nitric oxide, and the gene is expressed at high levels in vivo during the initial lung infection in mice. Enzyme activity is maintained during extended hypoxia even after transcription levels decrease. A knockout mutant shows no reduction in anaerobic survival in vitro, but results in a significant lag in the resumption of growth after reoxygenation. During reactivation the mutant has an altered NADH/NAD ratio	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)