Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-(4-(benzyloxy)benzylidene)-3-(2,5-dimethylphenyl)-2-iminothiazolidin-4-one | compound shows potency, selectivity, and no cytotoxicity up to 50 microM in a mouse macrophage cell line | Mycobacterium tuberculosis | |
5-(4-(benzyloxy)benzylidene)-3-(2,6-dimethylphenyl)-2-iminothiazolidin-4-one | compound shows potency, selectivity, and no cytotoxicity up to 50 microM in a mouse macrophage cell line | Mycobacterium tuberculosis | |
6-acetyl-2-(4-chlorobenzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide | compound shows potency, selectivity, and no cytotoxicity up to 50 microM in a mouse macrophage cell line | Mycobacterium tuberculosis | |
tert-butyl 3-carbamoyl-2-(4-chlorobenzamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate | compound shows potency, selectivity, and no cytotoxicity up to 50 microM in a mouse macrophage cell line | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.049 | - |
L-alanine | pH 10.2, 37°C | Mycobacterium tuberculosis | |
0.53 | - |
NAD+ | pH 10.2, 37°C | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WQB1 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WQB1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alanine + H2O + NAD+ | - |
Mycobacterium tuberculosis | pyruvate + NH3 + NADH + H+ | - |
? | |
L-alanine + H2O + NAD+ | - |
Mycobacterium tuberculosis H37Rv | pyruvate + NH3 + NADH + H+ | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00058 | - |
pH 10.2, 37°C | Mycobacterium tuberculosis | tert-butyl 3-carbamoyl-2-(4-chlorobenzamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate | |
0.00064 | - |
pH 10.2, 37°C | Mycobacterium tuberculosis | 6-acetyl-2-(4-chlorobenzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide | |
0.00134 | - |
pH 10.2, 37°C | Mycobacterium tuberculosis | 5-(4-(benzyloxy)benzylidene)-3-(2,5-dimethylphenyl)-2-iminothiazolidin-4-one | |
0.00174 | - |
pH 10.2, 37°C | Mycobacterium tuberculosis | 5-(4-(benzyloxy)benzylidene)-3-(2,6-dimethylphenyl)-2-iminothiazolidin-4-one |