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Literature summary for 1.4.1.1 extracted from

  • Pernil, R.; Herrero, A.; Flores, E.
    Catabolic function of compartmentalized alanine dehydrogenase in the heterocyst-forming cyanobacterium Anabaena sp. strain PCC 7120 (2010), J. Bacteriol., 192, 5165-5172.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of N-terminally GFP-fused enzyme in Anabaena sp. strain CSR30 Anabaena sp.

Protein Variants

Protein Variants Comment Organism
additional information inactivation of gene ald results in a lack of alanine dehydrogenase activity, a substantially decreased nitrogenase activity, and a 50% reduction in the rate of diazotrophic growth. While production of alanine is not affected in the ald mutant, alanine catabolism is hampered. Construction of several mutant strains, e,g, the insertion mutant strain CSR24, phenotypes, overview Anabaena sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-alanine + NAD+ + H2O Anabaena sp.
-
pyruvate + NH3 + NADH + H+
-
r
L-alanine + NAD+ + H2O Anabaena sp. PCC 7120
-
pyruvate + NH3 + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Anabaena sp.
-
gene ald, ORF alr2355
-
Anabaena sp. PCC 7120
-
gene ald, ORF alr2355
-

Source Tissue

Source Tissue Comment Organism Textmining
cyst expression in differentiating and mature heterocysts Anabaena sp.
-
additional information bubbled BG110C cultures Anabaena sp.
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0051
-
strain PCC 7120, pH 8.0, 25°C Anabaena sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanine + NAD+ + H2O
-
Anabaena sp. pyruvate + NH3 + NADH + H+
-
r
L-alanine + NAD+ + H2O
-
Anabaena sp. PCC 7120 pyruvate + NH3 + NADH + H+
-
r

Synonyms

Synonyms Comment Organism
ALD
-
Anabaena sp.

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Anabaena sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Anabaena sp.

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Anabaena sp.
NADH
-
Anabaena sp.

General Information

General Information Comment Organism
additional information alanine is transported from vegetative cells into heterocysts in the diazotrophic Anabaena filament Anabaena sp.
physiological function the enzyme is involved in the alanine catabolism in the heterocysts, that is needed for normal diazotrophic growth Anabaena sp.