Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,4,6-pregnatriene-3,20-dione | - |
Homo sapiens | |
1alpha,2alpha-epoxy-4,6-pregnadiene-3,20-dione | - |
Homo sapiens | |
20-hydroxyimino-1,4-pregnadiene-3-one | - |
Homo sapiens | |
20-hydroxyimino-4-pregnene-3-one | - |
Homo sapiens | |
20-hydroxyimino-5-oxo-A-nor-3,5-secopregnan-3-oic acid | - |
Homo sapiens | |
3beta-acetoxy-20-hydroxyimino-5-pregnene | - |
Homo sapiens | |
3beta-acetoxy-5-pregnen-20-one | - |
Homo sapiens | |
3beta-hydroxy-20-hydroxyiminopregnenolone | - |
Homo sapiens | |
4-aza-20-hydroxyimino-5-pregnene-3-one | an 4-azasteroid | Homo sapiens | |
5alpha,6alpha-epoxy-3beta-acetoxy-20-hydroxyiminopregnane | - |
Homo sapiens | |
5alpha,6alpha-epoxy-3beta-acetoxypregnan-20-one | - |
Homo sapiens | |
5alpha,6alpha-epoxy-3beta-hydroxypregnan-20-one | - |
Homo sapiens | |
5beta,6beta-epoxy-3beta-acetoxy-20-hydroxyiminopregnane | - |
Homo sapiens | |
5beta,6beta-epoxy-3beta-acetoxypregnan-20-one | - |
Homo sapiens | |
finasteride | - |
Homo sapiens | |
additional information | synthesis, enzyme inhibitory, and cell cytotoxicity of pregnan compounds, IC50 values for growth inhibition, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydrotestosterone + NADP+ | Homo sapiens | the enzyme performs conversion of testosterone to dihydrotestosterone | testosterone + NADPH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
LNCaP cell | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
prostate | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydrotestosterone + NADP+ | - |
Homo sapiens | testosterone + NADPH + H+ | - |
r | |
dihydrotestosterone + NADP+ | the enzyme performs conversion of testosterone to dihydrotestosterone | Homo sapiens | testosterone + NADPH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
5alpha-reductase | - |
Homo sapiens |
5alpha-reductase II | - |
Homo sapiens |
5AR2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
assay at | Homo sapiens |