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BRENDA support

Literature summary for 1.3.99.5 extracted from

  • Gleave, M.; Qian, J.; Andreou, C.; Pommerville, P.; Chin, J.; Casey, R.; Steinhoff, G.; Fleshner, N.; Bostwick, D.; Thomas, L.; Rittmaster, R.
    The effects of the dual 5alpha-reductase inhibitor dutasteride on localized prostate cancer - results from a 4-month pre-radical prostatectomy study (2006), Prostate, 66, 1674-1685.
    View publication on PubMed

Application

Application Comment Organism
medicine treatment of patients with clinically localized prostate cancer with enzyme inhibitor dutasteride before radical prostatectomy. Treatment with dutasteride is associated with reductions in serum and intraprostatic dihydrotestosterone of more than 90%, and a decrease in total prostate and tumor volumes. No effect of dutasteride is noted on Gleason grade Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
dutasteride inhibition of both isoform 1 and 2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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patients with clinically localized prostate cancer
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate gland
-
Homo sapiens
-