Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | expression of isozyme 5alpha-R2 is induced by testosterone and dihydrotestosterone | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
quantitative expression analysis of isozymes 5alpha-R1 and 5alpha-R2 in brain | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | expression of isozyme 5alpha-R1 is inhibited by testosterone and dihydrotestosterone | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxycorticosterone + reduced acceptor | Rattus norvegicus | - |
21-hydroxy-5alpha-pregnan-3,20-dione + acceptor | - |
? | |
additional information | Rattus norvegicus | the enzyme produces precursors for the biosynthesis of allopregnenolone and tetrahydrodeoxycorticosterone, physiological role of the isozymes in the brain, overview | ? | - |
? | |
progesterone + reduced acceptor | Rattus norvegicus | - |
pregnane-3,20-dione + acceptor | - |
? | |
testosterone + reduced acceptor | Rattus norvegicus | - |
5alpha-dihydrotestosterone + acceptor | 5alpha-dihydrotestosterone is a more potent androgen | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats, 2 isozymes 5alpha-R1 and 5alpha-R2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | adult, isozymes 5alpha-R1 and 5alpha-R2 | Rattus norvegicus | - |
cerebral cortex | prefrontal, expression of isozymes 5alpha-R1 and 5alpha-R2 | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxycorticosterone + reduced acceptor | - |
Rattus norvegicus | 21-hydroxy-5alpha-pregnan-3,20-dione + acceptor | - |
? | |
additional information | the enzyme produces precursors for the biosynthesis of allopregnenolone and tetrahydrodeoxycorticosterone, physiological role of the isozymes in the brain, overview | Rattus norvegicus | ? | - |
? | |
progesterone + reduced acceptor | - |
Rattus norvegicus | pregnane-3,20-dione + acceptor | - |
? | |
testosterone + reduced acceptor | - |
Rattus norvegicus | 5alpha-dihydrotestosterone + acceptor | - |
? | |
testosterone + reduced acceptor | - |
Rattus norvegicus | 5alpha-dihydrotestosterone + acceptor | 5alpha-dihydrotestosterone is a more potent androgen | ? |
Synonyms | Comment | Organism |
---|---|---|
5alpha-R | - |
Rattus norvegicus |
steroid 5alpha-reductase | - |
Rattus norvegicus |