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Literature summary for 1.3.99.5 extracted from

  • Torres, J.M.; Ortega, E.
    Differential regulation of steroid 5alpha-reductase isozymes expression by androgens in the adult rat brain (2003), FASEB J., 17, 1428-1433.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information expression of isozyme 5alpha-R2 is induced by testosterone and dihydrotestosterone Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
quantitative expression analysis of isozymes 5alpha-R1 and 5alpha-R2 in brain Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information expression of isozyme 5alpha-R1 is inhibited by testosterone and dihydrotestosterone Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxycorticosterone + reduced acceptor Rattus norvegicus
-
21-hydroxy-5alpha-pregnan-3,20-dione + acceptor
-
?
additional information Rattus norvegicus the enzyme produces precursors for the biosynthesis of allopregnenolone and tetrahydrodeoxycorticosterone, physiological role of the isozymes in the brain, overview ?
-
?
progesterone + reduced acceptor Rattus norvegicus
-
pregnane-3,20-dione + acceptor
-
?
testosterone + reduced acceptor Rattus norvegicus
-
5alpha-dihydrotestosterone + acceptor 5alpha-dihydrotestosterone is a more potent androgen ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male Wistar rats, 2 isozymes 5alpha-R1 and 5alpha-R2
-

Source Tissue

Source Tissue Comment Organism Textmining
brain adult, isozymes 5alpha-R1 and 5alpha-R2 Rattus norvegicus
-
cerebral cortex prefrontal, expression of isozymes 5alpha-R1 and 5alpha-R2 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxycorticosterone + reduced acceptor
-
Rattus norvegicus 21-hydroxy-5alpha-pregnan-3,20-dione + acceptor
-
?
additional information the enzyme produces precursors for the biosynthesis of allopregnenolone and tetrahydrodeoxycorticosterone, physiological role of the isozymes in the brain, overview Rattus norvegicus ?
-
?
progesterone + reduced acceptor
-
Rattus norvegicus pregnane-3,20-dione + acceptor
-
?
testosterone + reduced acceptor
-
Rattus norvegicus 5alpha-dihydrotestosterone + acceptor
-
?
testosterone + reduced acceptor
-
Rattus norvegicus 5alpha-dihydrotestosterone + acceptor 5alpha-dihydrotestosterone is a more potent androgen ?

Synonyms

Synonyms Comment Organism
5alpha-R
-
Rattus norvegicus
steroid 5alpha-reductase
-
Rattus norvegicus