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show all sequences of 1.3.99.23

An RNAi-based genetic screen for oxidative stress resistance reveals retinol saturase as a mediator of stress resistance

Nagaoka-Yasuda, R.; Matsuo, N.; Perkins, B.; Limbaeck-Stokin, K.; Mayford, M.; Free Radic. Biol. Med. 43, 781-788 (2007)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in NIH-3T3 cells and HEK-293 cells
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
a short hairpin RNA targeting retinol saturase strongly protects cells from tert-butylhydroperoxide and H2O2 by specifically reducing the expression of retinol saturase
Mus musculus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
Q64FW2
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
fibroblast
-
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
all-trans-retinol + reduced acceptor
-
686872
Mus musculus
all-trans-13,14-dihydroretinol + acceptor
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in NIH-3T3 cells and HEK-293 cells
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
a short hairpin RNA targeting retinol saturase strongly protects cells from tert-butylhydroperoxide and H2O2 by specifically reducing the expression of retinol saturase
Mus musculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
fibroblast
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
all-trans-retinol + reduced acceptor
-
686872
Mus musculus
all-trans-13,14-dihydroretinol + acceptor
-
-
-
?
Other publictions for EC 1.3.99.23
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
725598
Chen
The retinol signaling pathway ...
Mus musculus
J. Cell. Biochem.
112
2865-2872
2011
-
1
1
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
711959
Moise
Increased adiposity in the ret ...
Mus musculus
FASEB J.
24
1261-1270
2010
-
-
-
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
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-
-
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
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-
-
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-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
700301
Moise
Activation of retinoic acid re ...
Homo sapiens
Mol. Pharmacol.
76
1228-1237
2009
-
-
-
-
-
-
-
-
-
-
-
1
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2
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3
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1
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1
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3
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1
-
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-
-
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-
-
-
-
-
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-
-
-
-
700994
Schupp
Retinol saturase promotes adip ...
Homo sapiens, Mus musculus
Proc. Natl. Acad. Sci. USA
106
1105-1110
2009
4
2
2
-
4
-
-
-
-
-
2
2
-
3
-
-
-
-
-
5
-
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2
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-
-
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4
-
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-
4
2
2
4
-
4
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2
2
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5
-
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2
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-
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-
-
-
-
-
4
-
-
4
-
-
672228
Moise
Specificity of zebrafish retin ...
Danio rerio, Mus musculus
Biochemistry
46
1811-1820
2007
-
2
1
-
-
-
-
-
2
-
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-
7
-
-
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-
4
-
-
10
-
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-
-
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-
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2
2
-
-
-
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-
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-
2
-
-
-
-
-
-
-
-
6
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686872
Nagaoka-Yasuda
An RNAi-based genetic screen f ...
Mus musculus
Free Radic. Biol. Med.
43
781-788
2007
-
-
1
-
-
-
1
-
-
-
-
-
-
2
-
-
-
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-
1
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1
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1
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1
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1
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1
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-
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-
659486
Moise
Metabolism and transactivation ...
Mus musculus
J. Biol. Chem.
280
27815-27825
2005
-
-
-
-
-
-
-
-
-
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3
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1
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1
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659418
Moise
Identification of all-trans-re ...
Mus musculus
J. Biol. Chem.
279
50230-50242
2004
-
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1
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-
-
-
1
-
-
1
-
5
-
-
-
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-
3
-
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1
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1
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1
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1
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3
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1
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