Literature summary for 1.3.98.7 extracted from

Krishnamoorthy, G.; Kaiser, P.; Lozza, L.; Hahnke, K.; Mollenkopf, H.; Kaufmann, S.
Mycofactocin is associated with ethanol metabolism in mycobacteria (2019), mBio, 10, e00190 .

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Organism

Organism	UniProt	Comment	Textmining
Mycolicibacterium smegmatis	A0QSB8	-	-
Mycolicibacterium smegmatis ATCC 700084	A0QSB8	-	-

Synonyms

Synonyms	Comment	Organism
mftC	-	Mycolicibacterium smegmatis

General Information

General Information	Comment	Organism
physiological function	a MftC deletion mutant is unable to grow in minimal medium containing cholesterol (0.01% [wt/vol]) as the sole carbon source with hot ethanol (1% [vol/vol]) as the solvent (cholesterol and EtOH [cholesterol:EtOH]). There is no significant growth retardation in cholesterol:DMSO. Supplementation of ethanol has no effect on mutant strain growth in propionate (0.5% [wt/vol]) or glycerol (0.2% [vol/vol]) but severely delays mutant strain growth in acetate (0.5% [wt/vol]) in comparison with the growth of the wild-type strain. MftC deletion results in multifold increases in expression of the DosR regulon genes in ethanol-treated strains	Mycolicibacterium smegmatis

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Release 2023.1 (January 2023)