Literature summary for 1.3.98.1 extracted from

Nara, T.; Kamei, Y.; Tsubouchi, A.; Annoura, T.; Hirota, K.; Iizumi, K.; Dohmoto, Y.; Ono, T.; Aoki, T.
Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase activity and on the protozoan growth in mammalian cells (2005), Parasitol. Int., 54, 59-64.

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Application

Application	Comment	Organism
medicine	enzyme is inhibited by 59% and 58% by methanol extracts of the brown algae Fucus evanescens and Pelvetia babingtonii, resp., the extracts decrease significantly the infection rate of HeLa host cells and the average parasite number per infected cell	Trypanosoma cruzi

Inhibitors

Inhibitors	Comment	Organism	Structure
methanol extract of brown algae Fucus evanescens	59% inhibition, noncompetitive	Trypanosoma cruzi
methanol extract of brown algae Pelvetia babingtonii	58% inhibition, noncompetitive	Trypanosoma cruzi

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma cruzi	-	recombinant enzyme	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	Ki-values are 0.0353 and 0.0103 mg per ml for methanol extract of Fucus evanescens and Pelvetia babingtonii, resp.	Trypanosoma cruzi

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Release 2023.1 (January 2023)