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Literature summary for 1.3.98.1 extracted from

  • Rowland, P.; Bjornberg, O.; Nielsen, F.S.; Jensen, K.F.; Larsen, S.
    The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymic function (1998), Protein Sci., 7, 1269-1279.
    View publication on PubMedView publication on EuropePMC
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Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Lactococcus lactis
dihydroorotate dehydrogenase A, complexed with orotate Lactococcus lactis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-dihydroorotate + acceptor Lactococcus lactis fourth step in synthesis of pyrimidine nucleotides orotate + reduced acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Lactococcus lactis
-
-
-
Lactococcus lactis
-
 only enzyme A
-

Reaction

Reaction Comment Organism Reaction ID
(S)-dihydroorotate + fumarate = orotate + succinate the active site contains a water filled cavity buried beneath a highly conserved and flexible loop. Orotate is bound by four conserved asparagine side chains. Implications for differences in substrate binding and in the catalytic mechanism between the different enzyme families are given Lactococcus lactis
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-dihydroorotate + acceptor fourth step in synthesis of pyrimidine nucleotides Lactococcus lactis orotate + reduced acceptor
-
 ?
dihydroorotate + acceptor discussion of substrate binding and catalytic mechanism Lactococcus lactis orotate + reduced acceptor
-
 ?

Synonyms

Synonyms Comment Organism
DHOD
-
 Lactococcus lactis

Cofactor

Cofactor Comment Organism Structure
flavin
-
 Lactococcus lactis